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MedKoo Cat#: 574799 | Name: MRS-2179 tetrasodium salt
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

MRS-2179 tetrasodium salt is a competitive antagonist at P2Y1 receptors that inhibits the upregulation of NTPDase1 by ATPγS.

Chemical Structure

MRS-2179 tetrasodium salt
MRS-2179 tetrasodium salt
CAS# 1454889-37-2

Theoretical Analysis

MedKoo Cat#: 574799

Name: MRS-2179 tetrasodium salt

CAS#: 1454889-37-2

Chemical Formula: C11H13N5Na4O9P2

Exact Mass: 512.9779

Molecular Weight: 513.16

Elemental Analysis: C, 25.75; H, 2.55; N, 13.65; Na, 17.92; O, 28.06; P, 12.07

Price and Availability

Size Price Availability Quantity
10mg USD 410.00 2 Weeks
50mg USD 1,395.00 2 Weeks
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Related CAS #
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Synonym
MRS 2179 tetrasodium salt; MRS2179 tetrasodium salt; MRS-2179 tetrasodium salt
IUPAC/Chemical Name
2'-Deoxy-N6-methyladenosine 3',5'-bisphosphate tetrasodium salt
InChi Key
XLPQPYQWGFCKEY-ZKRIHRHSSA-J
InChi Code
InChI=1S/C11H17N5O9P2.4Na/c1-12-10-9-11(14-4-13-10)16(5-15-9)8-2-6(25-27(20,21)22)7(24-8)3-23-26(17,18)19;;;;/h4-8H,2-3H2,1H3,(H,12,13,14)(H2,17,18,19)(H2,20,21,22);;;;/q;4*+1/p-4/t6-,7+,8+;;;;/m0..../s1
SMILES Code
CNC(N=CN=C12)=C1N=CN2[C@H](O3)C[C@H](OP([O-])([O-])=O)[C@H]3COP([O-])([O-])=O.[Na+].[Na+].[Na+].[Na+]
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 513.16 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Boyer et al (1998) Competitive and selective antagonism of P2Y1 receptors by N6-methyl 2'-deoxyadenosine 3',5'-bisphosphate. Br.J.Pharmacol. 124 1 PMID: 9630335 2. Lu et al (2007) Stimulation of the P2Y1 receptor up-regulates nucleoside-triphosphate diphosphohydrolase-1 in human retinal pigment epithelial cells. J.Pharmacol.Exp.Ther. 323 157 PMID: 17626796 3. Nandanan et al (2000) Synthesis, biological activity, and molecular modeling of ribose-modified deoxyadenosine bisphosphate analogues as P2Y1 receptor ligands. J.Med.Chem. 43 829 PMID: 10715151 4. Brown et al (2000) Activity of novel adenine nucleotide derivatives as agonists and antagonists at recombinant rat P2X receptors. Drug Dev.Res. 49 253 PMID: 22791931 5. Nandanan et al (1999) Structure-activity relationships of bisphosphate nucleotide derivatives as P2Y1 receptor antagonists and partial agonists. J.Med.Chem. 42 1625 PMID: 10229631