MedKoo Cat#: 577771 | Name: MP-135

Description:

WARNING: This product is for research use only, not for human or veterinary use.

MP135 is a Novel μ−δ Opioid Receptor Heteromer-Selective Agonist. MP135 maintains untoward side effects such as respiratory depression and reward behavior; together, these results suggest that optimization of MP135 is necessary for the development of therapeutics that suppress the classical side effects associated with conventional clinical opioids.

Chemical Structure

MP-135
MP-135
CAS#2677687-49-7 (free base)

Theoretical Analysis

MedKoo Cat#: 577771

Name: MP-135

CAS#: 2677687-49-7 (free base)

Chemical Formula: C32H38FN3O2

Exact Mass: 515.2948

Molecular Weight: 515.67

Elemental Analysis: C, 74.53; H, 7.43; F, 3.68; N, 8.15; O, 6.21

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Synonym
MP-135; MP 135; MP135
IUPAC/Chemical Name
4-Piperidinecarboxamide, N-(2-(3-fluorophenyl)ethyl)-4-((1-oxopropyl)(phenylmethyl)amino)-1-(2-phenylethyl)-
InChi Key
SZQGSEKOXWECKF-UHFFFAOYSA-N
InChi Code
1S/C32H38FN3O2/c1-2-30(37)36(25-28-12-7-4-8-13-28)32(31(38)34-20-16-27-14-9-15-29(33)24-27)18-22-35(23-19-32)21-17-26-10-5-3-6-11-26/h3-15,24H,2,16-23,25H2,1H3,(H,34,38)
SMILES Code
CCC(=O)N(Cc1ccccc1)C2(CCN(CCc3ccccc3)CC2)C(=O)NCCc4cccc(F)c4
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 515.67 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Faouzi A, Uprety R, Gomes I, Massaly N, Keresztes AI, Le Rouzic V, Gupta A, Zhang T, Yoon HJ, Ansonoff M, Allaoa A, Pan YX, Pintar J, Morón JA, Streicher JM, Devi LA, Majumdar S. Synthesis and Pharmacology of a Novel μ-δ Opioid Receptor Heteromer-Selective Agonist Based on the Carfentanyl Template. J Med Chem. 2020 Nov 25;63(22):13618-13637. doi: 10.1021/acs.jmedchem.0c00901. Epub 2020 Nov 10. PMID: 33170687; PMCID: PMC7745089.