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MedKoo Cat#: 577755 | Name: Linvencorvir HCl

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Linvencorvir, also known as RG 7907 and RO7049389, is an orally available small molecule capsid protein inhibitor being developed by Roche for the treatment of chronic hepatitis B infections.

Chemical Structure

Linvencorvir HCl
CAS#Linvencorvir HCl

Theoretical Analysis

MedKoo Cat#: 577755

Name: Linvencorvir HCl

CAS#: Linvencorvir HCl

Chemical Formula: C29H36ClFN6O5S

Exact Mass: 0.0000

Molecular Weight: 635.15

Elemental Analysis: C, 54.84; H, 5.71; Cl, 5.58; F, 2.99; N, 13.23; O, 12.59; S, 5.05

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
Linvencorvir HCl 1808248-05-6 (free base)
Synonym
Linvencorvir HCl; RG-7907; RG7907; RG 7907; RO7049389; RO-7049389; RO 7049389;
IUPAC/Chemical Name
3-[(8aS)-7-{[(6S)-5-(ethoxycarbonyl)-6-(3-fluoro-2-methylphenyl)-2-(1,3-thiazol-2-yl)-1,6-dihydropyrimidin-4-yl]methyl}-3-oxohexahydroimidazo[1,5-a]pyrazin-2(3H)-yl]-2,2-dimethylpropanoic acid hydrochloride
InChi Key
KUJADJNJJQAWLW-JCNFZFLDSA-N
InChi Code
InChI=1S/C29H35FN6O5S.ClH/c1-5-41-26(37)22-21(15-34-10-11-36-18(13-34)14-35(28(36)40)16-29(3,4)27(38)39)32-24(25-31-9-12-42-25)33-23(22)19-7-6-8-20(30)17(19)2;/h6-9,12,18,23H,5,10-11,13-16H2,1-4H3,(H,32,33)(H,38,39);1H/t18-,23-;/m0./s1
SMILES Code
O=C(O)C(C)(C)CN(C1)C(N2[C@@]1([H])CN(CC3=C(C(OCC)=O)[C@H](C4=CC=CC(F)=C4C)NC(C5=NC=CS5)=N3)CC2)=O.[H]Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 635.15 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Gonçalves A, Lemenuel-Diot A, Cosson V, Jin Y, Feng S, Bo Q, Guedj J. What drives the dynamics of HBV RNA during treatment? J Viral Hepat. 2021 Feb;28(2):383-392. doi: 10.1111/jvh.13425. Epub 2020 Nov 2. PMID: 33074571.