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MedKoo Cat#: 465847 | Name: QC-308 HCl

Description:

WARNING: This product is for research use only, not for human or veterinary use.

QC-308 HCl is a novel Heme Oxygenase-1 Inhibitor (HO-1 IC50=0.27μM; HO-2 IC50=0.46μM).

Chemical Structure

QC-308 HCl
QC-308 HCl
CAS#1353586-18-1 (HCl)

Theoretical Analysis

MedKoo Cat#: 465847

Name: QC-308 HCl

CAS#: 1353586-18-1 (HCl)

Chemical Formula: C19H19ClN2O

Exact Mass: 326.1186

Molecular Weight: 326.82

Elemental Analysis: C, 69.83; H, 5.86; Cl, 10.85; N, 8.57; O, 4.90

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
1353712-58-9 (free base) 1353586-18-1 (HCl)
Synonym
QC-308 HCl; QC308 HCl; QC 308 HCl; QC-308 hydrochloride; QC308 hydrochloride; QC 308 hydrochloride;
IUPAC/Chemical Name
1-(1H-imidazol-1-yl)-4,4-diphenylbutan-2-one hydrochloride
InChi Key
PDSITLPEDYABLQ-UHFFFAOYSA-N
InChi Code
InChI=1S/C19H18N2O.ClH/c22-18(14-21-12-11-20-15-21)13-19(16-7-3-1-4-8-16)17-9-5-2-6-10-17;/h1-12,15,19H,13-14H2;1H
SMILES Code
O=C(CC(C1=CC=CC=C1)C2=CC=CC=C2)CN3C=CN=C3.[H]Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 326.82 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Rahman MN, Vlahakis JZ, Vukomanovic D, Lee W, Szarek WA, Nakatsu K, Jia Z. A novel, "double-clamp" binding mode for human heme oxygenase-1 inhibition. PLoS One. 2012;7(1):e29514. doi: 10.1371/journal.pone.0029514. Epub 2012 Jan 19. PMID: 22276118; PMCID: PMC3261875.

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