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MedKoo Cat#: 471104 | Name: SR 57227A (HCl)
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

SR 57227A HCl is a highly selective of central and peripheral 5-HT3 receptors and an inhibitor of NMDA receptor-mediated responses in rat cortical pyramidal cells. It exhibits anti-depressant like effects in rats and decreased isolation-induced aggressive behavior.

Chemical Structure

SR 57227A (HCl)
SR 57227A (HCl)
CAS#77145-61-0 (HCl)

Theoretical Analysis

MedKoo Cat#: 471104

Name: SR 57227A (HCl)

CAS#: 77145-61-0 (HCl)

Chemical Formula: C10H15Cl2N3

Exact Mass: 0.0000

Molecular Weight: 248.15

Elemental Analysis: C, 48.40; H, 6.09; Cl, 28.57; N, 16.93

Price and Availability

Size Price Availability Quantity
10mg USD 295.00 2 Weeks
25mg USD 600.00 2 Weeks
50mg USD 950.00 2 Weeks
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Related CAS #
77145-51-8 77145-61-0 (HCl)
Synonym
SR 57227A (HCl); SR-57227A (HCl); SR57227A (HCl)
IUPAC/Chemical Name
1-(6-chloropyridin-2-yl)piperidin-4-amine hydrochloride
InChi Key
FUMINTAAUJUVMP-UHFFFAOYSA-N
InChi Code
InChI=1S/C10H14ClN3.ClH/c11-9-2-1-3-10(13-9)14-6-4-8(12)5-7-14;/h1-3,8H,4-7,12H2;1H
SMILES Code
NC1CCN(C2=NC(Cl)=CC=C2)CC1.[H]Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 248.15 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Barbosa-Méndez S, Salazar-Juárez A. Evaluation of multitarget drugs on the expression of cocaine-induced locomotor sensitization in male rats: A comparative study. Heliyon. 2024 May 1;10(9):e29979. doi: 10.1016/j.heliyon.2024.e29979. PMID: 38726128; PMCID: PMC11079035. 2: Nakamura Y, Sumi T, Mitani O, Okamoto T, Kubo E, Masui K, Kondo M, Koyama Y, Usui N, Shimada S. SR 57227A, a serotonin type-3 receptor agonist, as a candidate analgesic agent targeting nociplastic pain. Biochem Biophys Res Commun. 2022 Sep 24;622:143-148. doi: 10.1016/j.bbrc.2022.07.027. Epub 2022 Jul 9. PMID: 35863088. 3: Mohammadi-Farani A, Taghadosi M, Raziee S, Samimi Z. In vivo blockade of 5HT3 receptors in the infralimbic medial prefrontal cortex enhances fear extinction in a rat model of PTSD. Iran J Basic Med Sci. 2021 Jun;24(6):776-786. doi: 10.22038/ijbms.2021.54299.12197. PMID: 34630955; PMCID: PMC8487606. 4: Nakamura Y, Kondo M, Koyama Y, Shimada S. SR 57227A is a partial agonist/partial antagonist of 5-HT3 receptor and inhibits subsequent 5-HT- or SR 57227A-induced 5-HT3 receptor current. Biochem Biophys Res Commun. 2019 Jan 8;508(2):590-596. doi: 10.1016/j.bbrc.2018.11.174. Epub 2018 Dec 1. PMID: 30509492. 5: Bell R, Duke AA, Gilmore PE, Page D, Bègue L. Anxiolytic-like effects observed in rats exposed to the elevated zero-maze following treatment with 5-HT2/5-HT3/5-HT4 ligands. Sci Rep. 2014 Jan 24;4:3881. doi: 10.1038/srep03881. PMID: 24457553; PMCID: PMC5379192. 6: Liu FC, Liou JT, Liao HR, Mao CC, Yang P, Day YJ. The anti-aggregation effects of ondansetron on platelets involve IP3 signaling and MAP kinase pathway, but not 5-HT3-dependent pathway. Thromb Res. 2012 Sep;130(3):e84-94. doi: 10.1016/j.thromres.2012.06.003. Epub 2012 Jul 18. PMID: 22818390. 7: Zhang QJ, Li LB, Niu XL, Liu J, Gui ZH, Feng JJ, Ali U, Hui YP, Wu ZH. The pyramidal neurons in the medial prefrontal cortex show decreased response to 5-hydroxytryptamine-3 receptor stimulation in a rodent model of Parkinson's disease. Brain Res. 2011 Apr 12;1384:69-79. doi: 10.1016/j.brainres.2011.01.086. Epub 2011 Feb 1. PMID: 21291871. 8: Gui ZH, Zhang QJ, Liu J, Ali U, Li LB, Wang Y, Wang T, Chen L, Hou C, Fan LL. In vivo modulation of the firing activity of putative slow- and fast-spiking interneurons in the medial prefrontal cortex by 5-HT3 receptors in 6-hydroxydopamine-induced Parkinsonian rats. Neuroscience. 2010 Sep 1;169(3):1315-25. doi: 10.1016/j.neuroscience.2010.05.059. Epub 2010 Jun 4. PMID: 20576497. 9: Guertin PA, Steuer I. Ionotropic 5-HT3 receptor agonist-induced motor responses in the hindlimbs of paraplegic mice. J Neurophysiol. 2005 Nov;94(5):3397-405. doi: 10.1152/jn.00587.2005. Epub 2005 Jul 27. PMID: 16049141. 10: Staner L, Linker T, Toussaint M, Danjou P, Roegel JC, Luthringer R, Le Fur G, Macher JP. Effects of the selective activation of 5-HT3 receptors on sleep: a polysomnographic study in healthy volunteers. Eur Neuropsychopharmacol. 2001 Aug;11(4):301-5. doi: 10.1016/s0924-977x(01)00099-2. PMID: 11532385. 11: Engel SR, Purdy RH, Grant KA. Characterization of discriminative stimulus effects of the neuroactive steroid pregnanolone. J Pharmacol Exp Ther. 2001 May;297(2):489-95. PMID: 11303034. 12: Maksay G. Bidirectional allosteric modulation of strychnine-sensitive glycine receptors by tropeines and 5-HT3 serotonin receptor ligands. Neuropharmacology. 1998 Dec;37(12):1633-41. doi: 10.1016/s0028-3908(98)00127-0. PMID: 9886686. 13: Watanabe K, Minabe Y, Ashby CR Jr, Katsumori H. Effect of acute administration of various 5-HT receptor agonists on focal hippocampal seizures in freely moving rats. Eur J Pharmacol. 1998 Jun 5;350(2-3):181-8. doi: 10.1016/s0014-2999(98)00255-6. PMID: 9696406. 14: Liang X, Arvanov VL, Wang RY. Inhibition of NMDA-receptor mediated response in the rat medial prefrontal cortical pyramidal cells by the 5-HT3 receptor agonist SR 57227A and 5-HT: intracellular studies. Synapse. 1998 Jul;29(3):257-68. doi: 10.1002/(SICI)1098-2396(199807)29:3<257::AID- SYN8>3.0.CO;2-5. PMID: 9635896. 15: Edwards E, Hampton E, Ashby CR, Zhang J, Wang RY. 5-HT3-like receptors in the rat medial prefrontal cortex: further pharmacological characterization. Brain Res. 1996 Sep 9;733(1):21-30. doi: 10.1016/0006-8993(96)00529-x. PMID: 8891244. 16: Maksay G. Distinct thermodynamic parameters of serotonin 5-HT3 agonists and antagonists to displace [3H]granisetron binding. J Neurochem. 1996 Jul;67(1):407-12. doi: 10.1046/j.1471-4159.1996.67010407.x. PMID: 8667020. 17: Poncelet M, Perio A, Simiand J, Gout G, Soubrie P, Le Fur G. Antidepressant- like effects of SR 57227A, a 5-HT3 receptor agonist, in rodents. J Neural Transm Gen Sect. 1995;102(2):83-90. doi: 10.1007/BF01276504. PMID: 8748673. 18: Zhang JY, Zeise ML, Wang RY. Serotonin3 receptor agonists attenuate glutamate-induced firing in rat hippocampal CA1 pyramidal cells. Neuropharmacology. 1994 Mar-Apr;33(3-4):483-91. doi: 10.1016/0028-3908(94)90079-5. PMID: 7984287. 19: Bachy A, Héaulme M, Giudice A, Michaud JC, Lefevre IA, Souilhac J, Manara L, Emerit MB, Gozlan H, Hamon M, et al. SR 57227A: a potent and selective agonist at central and peripheral 5-HT3 receptors in vitro and in vivo. Eur J Pharmacol. 1993 Jun 24;237(2-3):299-309. doi: 10.1016/0014-2999(93)90282-m. PMID: 7689975.