Zunsemetinib, also known as ATI-450 and CDD450, is a potent MK2 Inhibitor. ATI-450 binds with high affinity to the interface of the p38MAPK-MK2 complex and selectively inhibits p38MAPK-catalysed phosphorylation of MK2 which stabilises the inactive conformation of MK2, and subsequently reduces inflammatory cytokine levels. ATI-450 specifically blocks the downstream MK2-mediated inflammatory drive on the p38 pathway and may therefore avoid the tachyphylaxis associated with p38 inhibitors. Note CAS#1640282-42-3 is the active P-atropisomer. CAS# 1640282-44-5 is the inactive M-astropisomer.
MedKoo Cat#: 207172
Name: Zunsemetinib
CAS#: 1640282-42-3 (P-atropisomer)
Chemical Formula: C25H22ClF2N5O3
Exact Mass: 513.1379
Molecular Weight: 513.93
Elemental Analysis: C, 58.43; H, 4.31; Cl, 6.90; F, 7.39; N, 13.63; O, 9.34
| Solvent | mg/mL | mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 100.0 | 194.58 |
The following data is based on the product molecular weight 513.93 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
