JTP-59557 | CAS#540733-03-7 | NaPi inhibitor

MedKoo Cat#: 465749 | Name: JTP-59557

Description:

WARNING: This product is for research use only, not for human or veterinary use.

JTP-59557 is a potent, selective, stereospecific, noncompetitive inhibitor of intestinal Na/Pi cotransporters including type IIb, and it may represent a new class of intestinal Pi absorption inhibitor. TP-59557 showed an inhibitory effect on Na(+)-dependent inorganic phosphate (Pi) transport in intestinal brush border membrane vesicles with an IC(50) value of 0.40 microM in rabbit and with an IC(50) of 0.19 microM in rat, without affecting Na(+)-independent Pi and Na(+)-dependent d-glucose transport activities. In Chinese hamster ovary (CHO) cells expressing human type IIb Na/Pi cotransporter (type IIb), JTP-59557 decreased human type IIb-mediated Pi uptake with an IC(50) of 0.12 microM.

Chemical Structure

JTP-59557

CAS#540733-03-7

Theoretical Analysis

MedKoo Cat#: 465749

Name: JTP-59557

CAS#: 540733-03-7

Chemical Formula: C18H15Cl2F3N4OS

Exact Mass: 462.0296

Molecular Weight: 463.30

Elemental Analysis: C, 46.66; H, 3.26; Cl, 15.30; F, 12.30; N, 12.09; O, 3.45; S, 6.92

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

541502-05-0 540733-03-7

Synonym

JTP-59557; JTP59557; JTP 59557;

IUPAC/Chemical Name

4-(2-(tert-butyl)-4,5-dichlorophenyl)-5-((5-(trifluoromethyl)pyridin-2-yl)thio)-4H-1,2,4-triazol-3-ol

InChi Key

AKILCIXCGXREKT-UHFFFAOYSA-N

InChi Code

InChI=1S/C18H15Cl2F3N4OS/c1-17(2,3)10-6-11(19)12(20)7-13(10)27-15(28)25-26-16(27)29-14-5-4-9(8-24-14)18(21,22)23/h4-8H,1-3H3,(H,25,28)

SMILES Code

ClC1=C(Cl)C=C(N2C(SC3=NC=C(C(F)(F)F)C=C3)=NN=C2O)C(C(C)(C)C)=C1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 463.30 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Matsuo A, Negoro T, Seo T, Kitao Y, Shindo M, Segawa H, Miyamoto K. Inhibitory effect of JTP-59557, a new triazole derivative, on intestinal phosphate transport in vitro and in vivo. Eur J Pharmacol. 2005 Jul 4;517(1-2):111-9. doi: 10.1016/j.ejphar.2005.05.003. PMID: 15961073.