L319, also known as O-8670, Lipid 319; RV-92, is an ionizable lipid. It is useful for developing lipid nanoparticles (LNP) for siRNA, mRNA, and vaccine delivery. Lipid 319 nanoparticles have better delivery efficacy and biodegradability than DLin-MC3-DMA in the delivery of mRNA in vivo. MC3 is the key delivery nanoparticle component of the first siRNA drug Onpattro.
MedKoo Cat#: 465715
Name: L319
CAS#: 1351586-50-9
Chemical Formula: C41H75NO6
Exact Mass: 677.5594
Molecular Weight: 678.05
Elemental Analysis: C, 72.63; H, 11.15; N, 2.07; O, 14.16
The following data is based on the product molecular weight 678.05 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
