MedKoo Cat#: 471075 | Name: ASP2453
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

ASP2453 is a potent, selective and covalent KRAS G12C inhibitor.

Chemical Structure

ASP2453
ASP2453
CAS#2241719-73-1

Theoretical Analysis

MedKoo Cat#: 471075

Name: ASP2453

CAS#: 2241719-73-1

Chemical Formula: C40H48F3N7O4

Exact Mass: 747.3700

Molecular Weight: 747.86

Elemental Analysis: C, 64.24; H, 6.47; F, 7.62; N, 13.11; O, 8.56

Price and Availability

Size Price Availability Quantity
5mg USD 765.00 2 Weeks
10mg USD 1,150.00 2 Weeks
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Related CAS #
No Data
Synonym
ASP2453; ASP 2453; ASP-2453;
IUPAC/Chemical Name
1-(7-(6-cyclopropyl-2-((1-(3-methoxypropyl)piperidin-4-yl)oxy)-7-(5-methyl-1H-indazol-4-yl)-8-(2,2,2-trifluoroethoxy)quinazolin-4-yl)-2,7-diazaspiro[3.5]nonan-2-yl)prop-2-en-1-one
InChi Key
VEXDXXFHISGELS-UHFFFAOYSA-N
InChi Code
InChI=1S/C40H48F3N7O4/c1-4-32(51)50-22-39(23-50)12-17-49(18-13-39)37-29-20-28(26-7-8-26)34(33-25(2)6-9-31-30(33)21-44-47-31)36(53-24-40(41,42)43)35(29)45-38(46-37)54-27-10-15-48(16-11-27)14-5-19-52-3/h4,6,9,20-21,26-27H,1,5,7-8,10-19,22-24H2,2-3H3,(H,44,47)
SMILES Code
CC1=C(C2=C(OCC(F)(F)F)C3=NC(OC4CCN(CCCOC)CC4)=NC(N5CCC6(CN(C(C=C)=O)C6)CC5)=C3C=C2C7CC7)C(C=NN8)=C8C=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 747.86 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL