Synonym
MLT-827; MLT827; MLT 827;
IUPAC/Chemical Name
(S)-1-(5-chloro-6-methoxypyridin-3-yl)-3-(6-cyano-4-(3-methylmorpholino)quinolin-3-yl)urea
InChi Key
ZVTPIBKKYCMLDF-ZDUSSCGKSA-N
InChi Code
InChI=1S/C22H21ClN6O3/c1-13-12-32-6-5-29(13)20-16-7-14(9-24)3-4-18(16)25-11-19(20)28-22(30)27-15-8-17(23)21(31-2)26-10-15/h3-4,7-8,10-11,13H,5-6,12H2,1-2H3,(H2,27,28,30)/t13-/m0/s1
SMILES Code
N#CC1=CC2=C(N=CC(NC(NC3=CN=C(OC)C(Cl)=C3)=O)=C2N4CCOC[C@@H]4C)C=C1
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
452.90
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Unterreiner A, Touil R, Anastasi D, Dubois N, Niwa S, Calzascia T, Bornancin F. Myeloid Innate Signaling Pathway Regulation by MALT1 Paracaspase Activity. J Vis Exp. 2019 Jan 7;(143). doi: 10.3791/58439. PMID: 30663686.
2: Bardet M, Unterreiner A, Malinverni C, Lafossas F, Vedrine C, Boesch D, Kolb Y, Kaiser D, Glück A, Schneider MA, Katopodis A, Renatus M, Simic O, Schlapbach A, Quancard J, Régnier CH, Bold G, Pissot-Soldermann C, Carballido JM, Kovarik J, Calzascia T, Bornancin F. The T-cell fingerprint of MALT1 paracaspase revealed by selective inhibition. Immunol Cell Biol. 2018 Jan;96(1):81-99. doi: 10.1111/imcb.1018. Epub 2017 Dec 21. PMID: 29359407.
