MedKoo Cat#: 465686 | Name: NCX-1102

Description:

WARNING: This product is for research use only, not for human or veterinary use.

NCX-1102 is a NO-releasing NSAID compound.

Chemical Structure

NCX-1102
NCX-1102
CAS#unknown

Theoretical Analysis

MedKoo Cat#: 465686

Name: NCX-1102

CAS#: unknown

Chemical Formula: C24H24FNO6S

Exact Mass: 473.1308

Molecular Weight: 473.52

Elemental Analysis: C, 60.88; H, 5.11; F, 4.01; N, 2.96; O, 20.27; S, 6.77

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
NCX-1102; NCX1102; NCX 1102;
IUPAC/Chemical Name
4-(nitrooxy)butyl (Z)-2-(5-fluoro-2-methyl-1-(4-(methylsulfinyl)benzylidene)-1H-inden-3-yl)acetate
InChi Key
CMZSMYLJISCEDU-BKUYFWCQSA-N
InChi Code
InChI=1S/C24H24FNO6S/c1-16-21(13-17-5-8-19(9-6-17)33(2)30)20-10-7-18(25)14-23(20)22(16)15-24(27)31-11-3-4-12-32-26(28)29/h5-10,13-14H,3-4,11-12,15H2,1-2H3/b21-13-
SMILES Code
CS(C1=CC=C(/C=C2C(C)=C(CC(OCCCCO[N+]([O-])=O)=O)C3=CC(F)=CC=C3/2)C=C1)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 473.52 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Huguenin S, Vacherot F, Fleury-Feith J, Riffaud JP, Chopin DK, Bolla M, Jaurand MC. Evaluation of the antitumoral potential of different nitric oxide- donating non-steroidal anti-inflammatory drugs (NO-NSAIDs) on human urological tumor cell lines. Cancer Lett. 2005 Feb 10;218(2):163-70. doi: 10.1016/j.canlet.2004.06.003. PMID: 15670893. 2: Huguenin S, Fleury-Feith J, Kheuang L, Jaurand MC, Bolla M, Riffaud JP, Chopin DK, Vacherot F. Nitrosulindac (NCX 1102): a new nitric oxide-donating non-steroidal anti-inflammatory drug (NO-NSAID), inhibits proliferation and induces apoptosis in human prostatic epithelial cell lines. Prostate. 2004 Oct 1;61(2):132-41. doi: 10.1002/pros.20081. PMID: 15305336. 3: Huguenin S, Vacherot F, Kheuang L, Fleury-Feith J, Jaurand MC, Bolla M, Riffaud JP, Chopin DK. Antiproliferative effect of nitrosulindac (NCX 1102), a new nitric oxide-donating non-steroidal anti-inflammatory drug, on human bladder carcinoma cell lines. Mol Cancer Ther. 2004 Mar;3(3):291-8. PMID: 15026549. 4: Lavagna C, Burgaud JL, Del Soldato P, Rampal P. Antiproliferative effects of nitrosulindac on human colon adenocarcinoma cell lines. Biochem Biophys Res Commun. 2001 Jun 15;284(3):808-16. doi: 10.1006/bbrc.2001.5057. PMID: 11396974.