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MedKoo Cat#: 465681 | Name: MINC1

Description:

WARNING: This product is for research use only, not for human or veterinary use.

MINC1 is a novel GTPase-Activating Protein (GAP) Inhibitor, Targeting MgcRacGAP.

Chemical Structure

MINC1
MINC1
CAS#59886-58-3 (free base)

Theoretical Analysis

MedKoo Cat#: 465681

Name: MINC1

CAS#: 59886-58-3 (free base)

Chemical Formula: C16H16N4

Exact Mass: 264.1375

Molecular Weight: 264.33

Elemental Analysis: C, 72.70; H, 6.10; N, 21.20

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
59886-58-3 (free base) 259886-55-0 (HCl)
Synonym
MINC1; MINC 1; MINC-1;
IUPAC/Chemical Name
2,6-bis(4,5-dihydro-1H-imidazol-2-yl)naphthalene
InChi Key
WJDDYHHCAYVQTL-UHFFFAOYSA-N
InChi Code
InChI=1S/C16H16N4/c1-3-13(15-17-5-6-18-15)10-12-2-4-14(9-11(1)12)16-19-7-8-20-16/h1-4,9-10H,5-8H2,(H,17,18)(H,19,20)
SMILES Code
C1(C2=CC=C3C=C(C4=NCCN4)C=CC3=C2)=NCCN1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 264.33 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: van Adrichem AJ, Wennerberg K. MgcRacGAP inhibition stimulates JAK-dependent STAT3 activity. FEBS Lett. 2015 Dec 21;589(24 Pt B):3859-65. doi: 10.1016/j.febslet.2015.11.013. Epub 2015 Nov 19. PMID: 26602080. 2: van Adrichem AJ, Fagerholm A, Turunen L, Lehto A, Saarela J, Koskinen A, Repasky GA, Wennerberg K. Discovery of MINC1, a GTPase-activating protein small molecule inhibitor, targeting MgcRacGAP. Comb Chem High Throughput Screen. 2015;18(1):3-17. doi: 10.2174/1386207318666141205112730. PMID: 25479424; PMCID: PMC4435052. 3: Li J, Cusatis G, Brahmer J, Sparreboom A, Robey RW, Bates SE, Hidalgo M, Baker SD. Association of variant ABCG2 and the pharmacokinetics of epidermal growth factor receptor tyrosine kinase inhibitors in cancer patients. Cancer Biol Ther. 2007 Mar;6(3):432-8. doi: 10.4161/cbt.6.3.3763. Epub 2007 Mar 29. PMID: 17312388.