Relebactam, also known as MK-7655, is a non-β-lactam β-lactamase inhibitor that primarily targets class A (including KPC) and class C (AmpC) β-lactamases, thereby restoring the activity of β-lactam antibiotics such as imipenem. In combination with imipenem-cilastatin (marketed as Recarbrio), relebactam has shown potent in vitro activity against multidrug-resistant Gram-negative pathogens, particularly carbapenem-resistant Klebsiella pneumoniae and Pseudomonas aeruginosa. Minimum inhibitory concentration (MIC) data indicate that imipenem-relebactam reduces MIC values significantly compared to imipenem alone; for instance, the MIC₉₀ against P. aeruginosa is often ≤4 µg/mL versus >16 µg/mL for imipenem alone.
MedKoo Cat#: 577507
Name: Relebactam sodium
CAS#: 1502858-91-4 (sodium)
Chemical Formula: C12H19N4NaO6S
Exact Mass: 370.0923
Molecular Weight: 370.36
Elemental Analysis: C, 38.92; H, 5.17; N, 15.13; Na, 6.21; O, 25.92; S, 8.66
The following data is based on the product molecular weight 370.36 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
