VPC-13789 is a potent AR BF3 antagonist with markedly improved pharmacokinetic properties. VPC-13789 suppresses AR-mediated transcription, chromatin binding, and recruitment of coregulatory proteins. This novel AR antagonist selectively reduces the growth of both androgen-dependent and enzalutamide-resistant PCa cell lines. Having demonstrated in vitro efficacy an orally bioavailable prodrug was developed that reduced PSA production and tumor volume in animal models of CRPC with no observed toxicity.
MedKoo Cat#: 465627
Name: VPC-13789
CAS#: unknown
Chemical Formula: C18H10F3N3O
Exact Mass: 341.0776
Molecular Weight: 341.29
Elemental Analysis: C, 63.35; H, 2.95; F, 16.70; N, 12.31; O, 4.69
The following data is based on the product molecular weight 341.29 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
