Indophagolin is a potent, indoline-containing autophagy inhibitor (IC50=140 nM). Indophagolin is a representative member of an indoline-based class of autophagy inhibitors through a target-agnostic phenotypic assay. Thermal proteome profiling and subsequent biochemical validation identified the purinergic receptor P2X4 as a target of indophagolin, and subsequent investigations suggest that indophagolin targets further purinergic receptors.
MedKoo Cat#: 333069
Name: Indophagolin
CAS#: 1207660-00-1
Chemical Formula: C19H15BrClF3N2O3S
Exact Mass: 521.9627
Molecular Weight: 523.75
Elemental Analysis: C, 43.57; H, 2.89; Br, 15.26; Cl, 6.77; F, 10.88; N, 5.35; O, 9.16; S, 6.12
| Solvent | mg/mL | mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 250.0 | 477.33 |
The following data is based on the product molecular weight 523.75 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
