MedKoo Cat#: 146335 | Name: Crotoxyphos

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Crotoxyphos is an organophosphate insecticide and ectoparasiticide used primarily in veterinary medicine to control lice, flies, and other parasites on livestock. It functions by inhibiting acetylcholinesterase, leading to the accumulation of acetylcholine at nerve synapses and causing paralysis and death in target pests.

Chemical Structure

Crotoxyphos
Crotoxyphos
CAS#7700-17-6

Theoretical Analysis

MedKoo Cat#: 146335

Name: Crotoxyphos

CAS#: 7700-17-6

Chemical Formula: C14H19O6P

Exact Mass: 314.0919

Molecular Weight: 314.27

Elemental Analysis: C, 53.51; H, 6.09; O, 30.54; P, 9.86

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Crotoxyphos; Ciodrin;
IUPAC/Chemical Name
1-phenylethyl (E)-3-((dimethoxyphosphoryl)oxy)but-2-enoate
InChi Key
XXXSILNSXNPGKG-ZHACJKMWSA-N
InChi Code
1S/C14H19O6P/c1-11(20-21(16,17-3)18-4)10-14(15)19-12(2)13-8-6-5-7-9-13/h5-10,12H,1-4H3/b11-10+
SMILES Code
COP(=O)(OC)O\C(C)=C\C(=O)OC(C)C1=CC=CC=C1
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 314.27 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Azab HA, Khairy GM, Kamel RM. Time-resolved fluorescence sensing of pesticides chlorpyrifos, crotoxyphos and endosulfan by the luminescent Eu(III)-8-allyl-3-carboxycoumarin probe. Spectrochim Acta A Mol Biomol Spectrosc. 2015 Sep 5;148:114-24. doi: 10.1016/j.saa.2015.03.098. Epub 2015 Apr 4. PMID: 25875033. 2: Nillos MG, Rodriguez-Fuentes G, Gan J, Schlenk D. Enantioselective acetylcholinesterase inhibition of the organophosphorous insecticides profenofos, fonofos, and crotoxyphos. Environ Toxicol Chem. 2007 Sep;26(9):1949-54. doi: 10.1897/07-001R.1. PMID: 17705656. 3: Mohammad FK, St Omer VE. Interaction of dichlorvos-crotoxyphos insecticide with phenothiazine anthelmintic in sheep with or without Haemonchus and Trichostrongylus infections. Am J Vet Res. 1983 Oct;44(10):1949-53. PMID: 6685446. 4: Getzin LW, Satyanarayana T. Isolation of an enzyme from soil that degrades the organophosphorus insecticide, crotoxyphos. Arch Environ Contam Toxicol. 1979;8(6):661-72. doi: 10.1007/BF01054868. PMID: 43710. 5: Sreedhar NY, Rajendra Kumar Reddy P, Subba Reddy GV, Reddy SJ. Differential pulse polarographic determination of dicrotophos, crotoxyphos and chlorfenvinphos in grains and soils. Talanta. 1997 Oct;44(10):1859-63. doi: 10.1016/S0039-9140(97)00081-7. PMID: 18966927. 6: Rogers KR, Wang Y, Mulchandani A, Mulchandani P, Chen W. Organophosphorus hydrolase-based assay for organophosphate pesticides. Biotechnol Prog. 1999 May;15(3):517-21. doi: 10.1021/bp990034e. PMID: 10356272. 7: Palmer JS, Schlinke JC. Toxicologic effect of two crotoxyphos formulations on pigs. J Econ Entomol. 1971 Jun;64(3):684-5. doi: 10.1093/jee/64.3.684. PMID: 5558277. 8: Knapp FW. Prevention of cattle grub infestation in lactating dairy cows by use of daily applications of crotoxyphos. J Econ Entomol. 1972 Apr;65(2):466-7. doi: 10.1093/jee/65.2.466. PMID: 5062824. 9: Ellington JJ, Evans JJ, Prickett KB, Champion WL Jr. High-performance liquid chromatographic separation of the enantiomers of organophosphorus pesticides on polysaccharide chiral stationary phases. J Chromatogr A. 2001 Sep 14;928(2):145-54. doi: 10.1016/s0021-9673(01)01138-4. PMID: 11587332. 10: Scott JG, Roush RT, Liu N. Selection of high-level abamectin resistance from field-collected house flies, Musca domestica. Experientia. 1991 Mar 15;47(3):288-91. doi: 10.1007/BF01958163. PMID: 2009941. 11: Davey RB, Ahrens EH, George JE. Ovicidal activity of topically applied acaricides against eggs of the southern cattle tick (Acari: Ixodidae). J Econ Entomol. 1989 Apr;82(2):539-42. doi: 10.1093/jee/82.2.539. PMID: 2708632. 12: Garrett NE, Stack HF, Waters MD. Evaluation of the genetic activity profiles of 65 pesticides. Mutat Res. 1986 Nov;168(3):301-25. doi: 10.1016/0165-1110(86)90024-2. PMID: 3796654. 13: Haque MA, Hossain MS, Ahmad I, Akbor MA, Rahman A, Manir MS, Patel HM, Cho KM. Unveiling chlorpyrifos mineralizing and tomato plant-growth activities of Enterobacter sp. strain HSTU-ASh6 using biochemical tests, field experiments, genomics, and in silico analyses. Front Microbiol. 2022 Nov 29;13:1060554. doi: 10.3389/fmicb.2022.1060554. PMID: 36523825; PMCID: PMC9745158. 14: Brown LM, Blair A, Gibson R, Everett GD, Cantor KP, Schuman LM, Burmeister LF, Van Lier SF, Dick F. Pesticide exposures and other agricultural risk factors for leukemia among men in Iowa and Minnesota. Cancer Res. 1990 Oct 15;50(20):6585-91. PMID: 2208120. 15: Geden CJ, Rutz DA, Scott JG, Long SJ. Susceptibility of house flies (Diptera: Muscidae) and five pupal parasitoids (Hymenoptera: Pteromalidae) to abamectin and seven commercial insecticides. J Econ Entomol. 1992 Apr;85(2):435-40. doi: 10.1093/jee/85.2.435. PMID: 1593014. 16: Wright AJ, Nichols DB, Badcock JA. Control of headfly on sheep. Vet Rec. 1987 Jun 27;120(26):612-4. doi: 10.1136/vr.120.26.612. PMID: 3629871. 17: L'vova TS. Sravnitel'noe izuchenie na drozhzhakh rekombinogennogo deĭstviia riada pestitsidov pri otsutstvii i nalichii metabolichesskoĭ aktivatsii [Comparative studies of the recombinogenic action of some pesticides on yeasts in the absence and presence of metabolic activation]. Tsitol Genet. 1989 May- Jun;23(3):68-70. Russian. PMID: 2672478. 18: Natoff IL, Reiff B. Quantitative studies of the effect of antagonists on the acute toxicity of organophosphates in rats. Br J Pharmacol. 1970 Sep;40(1):124-34. doi: 10.1111/j.1476-5381.1970.tb10617.x. PMID: 5487002; PMCID: PMC1702683. 19: Scott JG, Geden CJ, Rutz DA, Liu NN. Comparative toxicity of seven insecticides to immature stages of Musca domestica (Diptera: Muscidae) and two of its important biological control agents, Muscidifurax raptor and Spalangia cameroni (Hymenoptera: Pteromalidae). J Econ Entomol. 1991 Jun;84(3):776-9. doi: 10.1093/jee/84.3.776. PMID: 1885842. 20: L'vova TS. Izuchenie mutagennogo deĭstviia piati perspektivnykh pestitsidov na kostnom mozge mysheĭ, v kul'ture limfotsitov perifericheskoĭ krovi cheloveka i na drozhzhakh-sakharomitsetakh [Mutagenic action of 5 prospective pesticides on mouse bone marrow, in a culture of human peripheral blood lymphocytes and on saccharomycete yeasts]. Tsitol Genet. 1984 Nov-Dec;18(6):455-7. Russian. PMID: 6395457.