JPI 547, also known as NOV 1402, is an oral inhibitor of PARP 1/2 and Tankyrase 1/2. JPI-547 demonstrated anti-tumor activity in BRCA-deficient xenograft models as a single-agent and in combination with chemotherapy and immune checkpoint inhibitors.
MedKoo Cat#: 408162
Name: JPI-547 HCl
CAS#: 2055357-65-6 (HCl)
Chemical Formula: C23H26Cl2N6O
Exact Mass:
Molecular Weight: 473.40
Elemental Analysis: C, 58.35; H, 5.54; Cl, 14.98; N, 17.75; O, 3.38
The following data is based on the product molecular weight 473.40 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
