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MedKoo Cat#: 465604 | Name: Cyanine 5.5, SE

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Cyanine 5.5, SE is a far red fluorescent dye for the labeling of amines. Cyanine 5.5, SE is ideal for labeling antibodies, peptides, glycoproteins, and amine-rich proteins. Cyanine 5.5, SE is also suitable for in vivo imaging. Excitation maximum ~675 nm; emission maximum ~694 nm.

Chemical Structure

Cyanine 5.5, SE
Cyanine 5.5, SE
CAS#unknown

Theoretical Analysis

MedKoo Cat#: 465604

Name: Cyanine 5.5, SE

CAS#: unknown

Chemical Formula: C63H92N6O16S4

Exact Mass: 1316.5453

Molecular Weight: 1317.70

Elemental Analysis: C, 57.43; H, 7.04; N, 6.38; O, 19.43; S, 9.73

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Related CAS #
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Synonym
Cyanine 5.5, SE; Cyanine 5.5 SE; Cyanine 5.5-SE; Cy5.5; Cy-5.5; Cy 5.5; Sulpho-Cyanine 5.5; Sulpho-Cyanine-5.5; Sulpho Cyanine 5.5; Sulpho Cyanine-5.5;
IUPAC/Chemical Name
triethylammonium 3-(6-((2,5-dioxopyrrolidin-1-yl)oxy)-6-oxohexyl)-2-((1E,3E,5Z)-5-(3-ethyl-1,1-dimethyl-6,8-disulfonato-1,3-dihydro-2H-benzo[e]indol-2-ylidene)penta-1,3-dien-1-yl)-1,1-dimethyl-1H-benzo[e]indol-3-ium-6,8-disulfonate
InChi Key
GECMOSJJYVCJFX-UHFFFAOYSA-N
InChi Code
InChI=1S/C45H47N3O16S4.3C6H15N/c1-6-46-33-18-16-29-31(23-27(65(52,53)54)25-35(29)67(58,59)60)42(33)44(2,3)37(46)13-9-7-10-14-38-45(4,5)43-32-24-28(66(55,56)57)26-36(68(61,62)63)30(32)17-19-34(43)47(38)22-12-8-11-15-41(51)64-48-39(49)20-21-40(48)50;3*1-4-7(5-2)6-3/h7,9-10,13-14,16-19,23-26H,6,8,11-12,15,20-22H2,1-5H3,(H3-,52,53,54,55,56,57,58,59,60,61,62,63);3*4-6H2,1-3H3
SMILES Code
CCN1C2=C(C3=CC(S([O-])(=O)=O)=CC(S([O-])(=O)=O)=C3C=C2)C(/C1=C/C=C/C=C/C4=[N+](CCCCCC(ON5C(CCC5=O)=O)=O)C6=C(C7=CC(S([O-])(=O)=O)=CC(S([O-])(=O)=O)=C7C=C6)C4(C)C)(C)C.CC[N+]([H])(CC)CC.CC[N+]([H])(CC)CC.CC[N+]([H])(CC)CC
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Solvent mg/mL mM
Solubility
DMSO 10.0 8.00
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 1,317.70 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Tian R, Wang C, Chi W, Fan J, Du J, Long S, Guo L, Liu X, Peng X. Emerging Design Principle of Near-Infrared Upconversion Sensitizer Based on Mitochondria- Targeted Organic Dye for Enhanced Photodynamic Therapy. Chemistry. 2021 Oct 14. doi: 10.1002/chem.202102866. Epub ahead of print. PMID: 34648222. 2: Liang Z, Hao C, Chen C, Ma W, Sun M, Xu L, Xu C, Kuang H. Ratiometric FRET encoded Hierarchical ZrMOF@Au Cluster for Ultrasensitive Quantifying MicroRNA in vivo. Adv Mater. 2021 Oct 14:e2107449. doi: 10.1002/adma.202107449. Epub ahead of print. PMID: 34647652. 3: Guo H, Liu L, Hu Q, Dou H. Monodisperse ZIF-8@dextran nanoparticles co-loaded with hydrophilic and hydrophobic functional cargos for combined near-infrared fluorescence imaging and photothermal therapy. Acta Biomater. 2021 Oct 9:S1742-7061(21)00665-6. doi: 10.1016/j.actbio.2021.10.006. Epub ahead of print. PMID: 34637934. 4: Lin AD, Tung MC, Lu CH. The hernia sac-A suitable source for obtaining mesenchymal stem cells. Surg Open Sci. 2021 Aug 28;6:40-44. doi: 10.1016/j.sopen.2021.08.002. PMID: 34632354; PMCID: PMC8487083. 5: Kwak MH, Yang SM, Yun SK, Kim S, Choi MG, Park JM. Identification and validation of LGR5-binding peptide for molecular imaging of gastric cancer. Biochem Biophys Res Commun. 2021 Nov 26;580:93-99. doi: 10.1016/j.bbrc.2021.09.073. Epub 2021 Oct 2. PMID: 34628260. 6: Chen Z, Peng Y, Li Y, Xie X, Wei X, Yang G, Zhang H, Li N, Li T, Qin X, Li S, Wu C, You F, Yang H, Liu Y. Aptamer-Dendrimer Functionalized Magnetic Nano- Octahedrons: Theranostic Drug/Gene Delivery Platform for Near-Infrared/Magnetic Resonance Imaging-Guided Magnetochemotherapy. ACS Nano. 2021 Sep 29. doi: 10.1021/acsnano.1c06667. Epub ahead of print. PMID: 34586789. 7: Rizvi SFA, Shahid S, Mu S, Zhang H. Hybridization of tumor homing and mitochondria-targeting peptide domains to design novel dual-imaging self- assembled peptide nanoparticles for theranostic applications. Drug Deliv Transl Res. 2021 Sep 17. doi: 10.1007/s13346-021-01066-6. Epub ahead of print. PMID: 34535874. 8: Fan Q, Wang C, Guo R, Jiang X, Li W, Chen X, Li K, Hong W. Step-by-step dual stimuli-responsive nanoparticles for efficient bacterial biofilm eradication. Biomater Sci. 2021 Oct 12;9(20):6889-6902. doi: 10.1039/d1bm01038g. PMID: 34519743. 9: Zhukova V, Osipova N, Semyonkin A, Malinovskaya J, Melnikov P, Valikhov M, Porozov Y, Solovev Y, Kuliaev P, Zhang E, Sabel BA, Chekhonin V, Abakumov M, Majouga A, Kreuter J, Henrich-Noack P, Gelperina S, Maksimenko O. Fluorescently Labeled PLGA Nanoparticles for Visualization In Vitro and In Vivo: The Importance of Dye Properties. Pharmaceutics. 2021 Jul 27;13(8):1145. doi: 10.3390/pharmaceutics13081145. PMID: 34452106; PMCID: PMC8399891. 10: Wang Y, Li Y, Cao J, Meng Q, Li X, Zhang Y, Lam KS, Hong A, Liu R, Chen X. Development and Characterization of a Novel Peptide-Drug Conjugate with DM1 for Treatment of FGFR2-Positive Tumors. Biomedicines. 2021 Jul 21;9(8):849. doi: 10.3390/biomedicines9080849. PMID: 34440055; PMCID: PMC8389697. 11: He L, Ye S, Fang J, Zhang Y, Cui C, Wang A, Zhao Y, Shi H. Real-Time Visualization of Embryonic Apoptosis Using a Near-Infrared Fluorogenic Probe for Embryo Development Evaluation. Anal Chem. 2021 Sep 7;93(35):12122-12130. doi: 10.1021/acs.analchem.1c02793. Epub 2021 Aug 23. PMID: 34424664. 12: Zhao Y, Shirasu T, Yodsanit N, Kent E, Ye M, Wang Y, Xie R, Gregg AC, Huang Y, Kent KC, Guo LW, Gong S, Wang B. Biomimetic, ROS-detonable nanoclusters - A multimodal nanoplatform for anti-restenotic therapy. J Control Release. 2021 Oct 10;338:295-306. doi: 10.1016/j.jconrel.2021.08.025. Epub 2021 Aug 18. PMID: 34416322. 13: Wang SS, Liu ZK, Liu JJ, Cheng Q, Wang YX, Liu Y, Ni WW, Chen HZ, Song M. Imaging asparaginyl endopeptidase (AEP) in the live brain as a biomarker for Alzheimer's disease. J Nanobiotechnology. 2021 Aug 19;19(1):249. doi: 10.1186/s12951-021-00988-0. PMID: 34412639; PMCID: PMC8375181. 14: Tamarov K, Wang JT, Kari J, Happonen E, Vesavaara I, Niemelä M, Perämäki P, Al-Jamal KT, Xu W, Lehto VP. Comparison between Fluorescence Imaging and Elemental Analysis to Determine Biodistribution of Inorganic Nanoparticles with Strong Light Absorption. ACS Appl Mater Interfaces. 2021 Sep 1;13(34):40392-40400. doi: 10.1021/acsami.1c11875. Epub 2021 Aug 16. PMID: 34405988; PMCID: PMC8414481. 15: Zeng W, Wu L, Sun Y, Wang Y, Wang J, Ye D. Ratiometric Imaging of MMP-2 Activity Facilitates Tumor Detection Using Activatable Near-Infrared Fluorescent Semiconducting Polymer Nanoparticles. Small. 2021 Sep;17(36):e2101924. doi: 10.1002/smll.202101924. Epub 2021 Jul 26. PMID: 34309199. 16: Xu L, Song H, Qiu Q, Jiang T, Ge P, Su Z, Ma W, Zhang R, Huang C, Li S, Lin D, Zhang J. Different Expressions of HIF-1α and Metabolism in Brain and Major Visceral Organs of Acute Hypoxic Mice. Int J Mol Sci. 2021 Jun 23;22(13):6705. doi: 10.3390/ijms22136705. PMID: 34201416; PMCID: PMC8268807. 17: Qiu P, Xu Y. The construction of multifunctional nanoparticles system for dual-modal imaging and arteriosclerosis targeted therapy. Am J Transl Res. 2021 May 15;13(5):4026-4039. PMID: 34149996; PMCID: PMC8205662. 18: Peng X, Chen K, Liu W, Cao X, Wang M, Tao J, Tian Y, Bao L, Lu G, Teng Z. Soft Mesoporous Organosilica Nanoplatforms Improve Blood Circulation, Tumor Accumulation/Penetration, and Photodynamic Efficacy. Nanomicro Lett. 2020 Jun 30;12(1):137. doi: 10.1007/s40820-020-00465-7. PMID: 34138135; PMCID: PMC7770801. 19: Kang X, Li M, Liu L, Liu S, Hu H, Zhang R, Ning S, Tian Z, Pan Y, Guo X, Wu K. Targeted imaging of esophageal adenocarcinoma with a near-infrared fluorescent peptide. BMC Gastroenterol. 2021 Jun 12;21(1):260. doi: 10.1186/s12876-021-01840-3. PMID: 34118882; PMCID: PMC8199829. 20: Zhang E, Osipova N, Sokolov M, Maksimenko O, Semyonkin A, Wang M, Grigartzik L, Gelperina S, Sabel BA, Henrich-Noack P. Exploring the systemic delivery of a poorly water-soluble model drug to the retina using PLGA nanoparticles. Eur J Pharm Sci. 2021 Sep 1;164:105905. doi: 10.1016/j.ejps.2021.105905. Epub 2021 Jun 8. PMID: 34116175.

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