Ac18Az8 | CAS#unknown | BCRP inhibitor

MedKoo Cat#: 465586 | Name: Ac18Az8

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Ac18Az8 is a potent, nontoxic, and highly selective BCRP inhibitor (EC50 = 1−15 nM).

Chemical Structure

Ac18Az8

CAS#unknown

Theoretical Analysis

MedKoo Cat#: 465586

Name: Ac18Az8

CAS#: unknown

Chemical Formula: C39H38N4O7

Exact Mass: 674.2740

Molecular Weight: 674.75

Elemental Analysis: C, 69.42; H, 5.68; N, 8.30; O, 16.60

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

Ac18Az8; Ac18 Az8 Ac18-Az8;

IUPAC/Chemical Name

methyl 3-(((4-oxo-2-(4-(2-(2-(4-((phenethylamino)methyl)-1H-1,2,3-triazol-1-yl)ethoxy)ethoxy)phenyl)-4H-chromen-3-yl)oxy)methyl)benzoate

InChi Key

RWDWWKMEXQFULX-UHFFFAOYSA-N

InChi Code

InChI=1S/C39H38N4O7/c1-46-39(45)31-11-7-10-29(24-31)27-49-38-36(44)34-12-5-6-13-35(34)50-37(38)30-14-16-33(17-15-30)48-23-22-47-21-20-43-26-32(41-42-43)25-40-19-18-28-8-3-2-4-9-28/h2-17,24,26,40H,18-23,25,27H2,1H3

SMILES Code

O=C(OC)C1=CC=CC(COC2=C(C3=CC=C(OCCOCCN4N=NC(CNCCC5=CC=CC=C5)=C4)C=C3)OC6=C(C=CC=C6)C2=O)=C1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 674.75 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Wong ILK, Zhu X, Chan KF, Liu Z, Chan CF, Chow TS, Chong TC, Law MC, Cui J, Chow LMC, Chan TH. Flavonoid Monomers as Potent, Nontoxic, and Selective Modulators of the Breast Cancer Resistance Protein (ABCG2). J Med Chem. 2021 Oct 4. doi: 10.1021/acs.jmedchem.1c00779. Epub ahead of print. PMID: 34606270.