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MedKoo Cat#: 574571 | Name: Azamulin
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Azamulin is a selective, irreversible inhibitor of cytochrome P450 (CYP) 3A isoforms. Azamulin potently blocks the hydroxylation of testosterone and midazolam by CYP3A4.

Chemical Structure

Azamulin
Azamulin
CAS#76530-44-4

Theoretical Analysis

MedKoo Cat#: 574571

Name: Azamulin

CAS#: 76530-44-4

Chemical Formula: C24H38N4O4S

Exact Mass: 478.2614

Molecular Weight: 478.65

Elemental Analysis: C, 60.22; H, 8.00; N, 11.71; O, 13.37; S, 6.70

Price and Availability

Size Price Availability Quantity
1mg USD 300.00 2 Weeks
5mg USD 650.00 2 Weeks
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Related CAS #
No Data
Synonym
Antibiotic TDM 85-530; Azamulin; SA 85530b
IUPAC/Chemical Name
(3aR,4R,5R,7R,8S,9R,9aS,12R)-7-ethyl-8-hydroxy-4,7,9,12-tetramethyl-3-oxodecahydro-4,9a-propanocyclopenta[8]annulen-5-yl 2-((5-amino-4H-1,2,4-triazol-3-yl)thio)acetate
InChi Key
FMHQJXGMLMSMLC-WBUYAQKGSA-N
InChi Code
InChI=1S/C24H38N4O4S/c1-6-22(4)11-16(32-17(30)12-33-21-26-20(25)27-28-21)23(5)13(2)7-9-24(14(3)19(22)31)10-8-15(29)18(23)24/h13-14,16,18-19,31H,6-12H2,1-5H3,(H3,25,26,27,28)/t13-,14+,16-,18+,19+,22-,23+,24+/m1/s1
SMILES Code
O=C1CC[C@@]23[C@@H](C)[C@H](O)[C@@](CC)(C)C[C@@H](OC(CSC4=NN=C(N)N4)=O)[C@](C)([C@H](C)CC3)[C@@]21[H]
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 478.65 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
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Poult Sci. 2024 Sep;103(9):103971. doi: 10.1016/j.psj.2024.103971. Epub 2024 Jun 11. PMID: 38941788; PMCID: PMC11260365. 7: Wu J, Liu H, Chen M, Xu J, Ji W. [Comparative metabolomics analysis of metabolic pathways in the high-yielding mutant strain of avilamycin]. Sheng Wu Gong Cheng Xue Bao. 2024 Jun 25;40(6):1868-1881. Chinese. doi: 10.13345/j.cjb.230683. PMID: 38914497. 8: Xu H, Gong J, Lu P, Azevedo P, Li L, Yu H, Yang C. Functional evaluation of Bacillus licheniformis PF9 for its potential in controlling enterotoxigenic Escherichia coli in weaned piglets. Transl Anim Sci. 2024 Apr 3;8:txae050. doi: 10.1093/tas/txae050. PMID: 38665217; PMCID: PMC11044710. 9: Zhang D, Wang Y, Tang Q, Zhang Q, Ji X, Qiu X, Chen D, Liu W. An NADH/NAD+-favored aldo-keto reductase facilitates avilamycin A biosynthesis by primarily catalyzing oxidation of avilamycin C. Appl Environ Microbiol. 2024 Apr 17;90(4):e0015024. doi: 10.1128/aem.00150-24. Epub 2024 Mar 29. PMID: 38551341; PMCID: PMC11022570. 10: Abdel-Latif MA, El-Hamid HSA, Emam M, Noreldin AE, Helmy YA, El-Far AH, Elbestawy AR. Dietary lysozyme and avilamycin modulate gut health, immunity, and growth rate in broilers. BMC Vet Res. 2024 Jan 20;20(1):28. doi: 10.1186/s12917-023-03871-2. PMID: 38245745; PMCID: PMC10799510. 11: Vimon S, Angkanaporn K, Nuengjamnong C. Microencapsulation of Lactobacillus plantarum MB001 and its probiotic effect on growth performance, cecal microbiome and gut integrity of broiler chickens in a tropical climate. Anim Biosci. 2023 Aug;36(8):1252-1262. doi: 10.5713/ab.22.0426. Epub 2023 May 2. PMID: 37170518; PMCID: PMC10330975. 12: Rodríguez SP, Herrera AL, Parra JE. Gene expression of pro-inflammatory (IL-8, IL-18, TNF-α, and IFN-γ) and anti-inflammatory (IL-10) cytokines in the duodenum of broiler chickens exposed to lipopolysaccharides from Escherichia coli and Bacillus subtilis. Vet World. 2023 Mar;16(3):564-570. doi: 10.14202/vetworld.2023.564-570. Epub 2023 Mar 22. PMID: 37041838; PMCID: PMC10082750. 13: Simjee S, Gould G, Maduro L, Boulianne M, Pridmore A, Parent E. No change in avilamycin (Surmax® Premix) minimum inhibitory concentration for Clostridium perfringens isolates recovered from poultry up to 7 years post-approval in Canada. J Antimicrob Chemother. 2023 May 3;78(5):1278-1281. doi: 10.1093/jac/dkad089. PMID: 36995979. 14: Qi N, Liu S, Yan F, Chen B, Wu S, Lin X, Yan Z, Zhou Q, Liao S, Li J, Lv M, Cai H, Hu J, Zhang J, Gu Y, Sun M. Study of microencapsulated fatty acid antimicrobial activity in vitro and its prevention ability of Clostridium perfringens induced necrotic enteritis in broiler chicken. Gut Pathog. 2023 Jan 2;15(1):1. doi: 10.1186/s13099-022-00526-9. PMID: 36593526; PMCID: PMC9808942. 15: Blokker B, Bortoluzzi C, Iaconis C, Perez-Calvo E, Walsh MC, Schyns G, Tamburini I, Geremia JM. 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Development of a highly sensitive monoclonal antibody-based indirect competitive enzyme-linked immunosorbent assay for the detection of avilamycin in feed. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2022 Mar;39(3):488-498. doi: 10.1080/19440049.2021.2017003. Epub 2022 Jan 21. PMID: 35061576. 19: Thuekeaw S, Angkanaporn K, Nuengjamnong C. Microencapsulated basil oil (Ocimum basilicum Linn.) enhances growth performance, intestinal morphology, and antioxidant capacity of broiler chickens in the tropics. Anim Biosci. 2022 May;35(5):752-762. doi: 10.5713/ab.21.0299. Epub 2022 Jan 3. PMID: 34991219; PMCID: PMC9065782. 20: Yang C, Diarra MS, Choi J, Rodas-Gonzalez A, Lepp D, Liu S, Lu P, Mogire M, Gong J, Wang Q, Yang C. Effects of encapsulated cinnamaldehyde on growth performance, intestinal digestive and absorptive functions, meat quality and gut microbiota in broiler chickens. Transl Anim Sci. 2021 Jun 1;5(3):txab099. doi: 10.1093/tas/txab099. 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