MedKoo Cat#: 471052 | Name: AZ7550 Mesylate
Featured

Description:

WARNING: This product is for research use only, not for human or veterinary use.

AZ7550 Mesylate is an active metabolite of AZD9291 (Osimertinib) and inhibits the activity of IGF1R with an IC50 of 1.6 μM.

Chemical Structure

AZ7550 Mesylate
AZ7550 Mesylate
CAS#2319837-99-3 (mesylate)

Theoretical Analysis

MedKoo Cat#: 471052

Name: AZ7550 Mesylate

CAS#: 2319837-99-3 (mesylate)

Chemical Formula: C30H43N7O11S3

Exact Mass: 0.0000

Molecular Weight: 773.89

Elemental Analysis: C, 46.56; H, 5.60; N, 12.67; O, 22.74; S, 12.43

Price and Availability

Size Price Availability Quantity
5mg USD 495.00 2 Weeks
Bulk Inquiry
Buy Now
Add to Cart
Related CAS #
Synonym
AZ-7550 Mesylate, AZ7550 Mesylate, AZ 7550 Mesylate
IUPAC/Chemical Name
N-(4-Methoxy-2-(methyl(2-(methylamino)ethyl)amino)-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin2-yl)amino)phenyl)acrylamide trimethanesulfonate
InChi Key
AZRGPJKRGFXCLD-UHFFFAOYSA-N
InChi Code
InChI=1S/C27H31N7O2.3CH4O3S/c1-6-26(35)30-21-15-22(25(36-5)16-24(21)33(3)14-13-28-2)32-27-29-12-11-20(31-27)19-17-34(4)23-10-8-7-9-18(19)23;3*1-5(2,3)4/h6-12,15-17,28H,1,13-14H2,2-5H3,(H,30,35)(H,29,31,32);3*1H3,(H,2,3,4)
SMILES Code
C=CC(NC1=CC(NC2=NC=CC(C3=CN(C)C4=C3C=CC=C4)=N2)=C(OC)C=C1N(C)CCNC)=O.CS(=O)(O)=O.CS(=O)(O)=O.CS(=O)(O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
1. Finlay MR, et al. Discovery of a potent and selective EGFR inhibitor (AZD9291) of both sensitizing and T790M resistance mutations that spares the wild type form of the receptor. J Med Chem. 2014 Oct 23;57(20):8249-67.

Preparing Stock Solutions

The following data is based on the product molecular weight 773.89 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL