QL-X-138 is a BTK and MNK inhibitor. QL-X-138 was found to inhibit BTK, MNK1, and MNK2 with IC50’s of 9.4, 107.4, and 26 nM, respectively. QL-X-138 exhibited good kinase selectivity with a score of 0.01, despite JAK3 inhibition with an IC50 of 55.7 nM. QL-X-138 exhibited GI50 values ranging from submicromolar to low micromolar levels against a panel of cancer cell lines.
MedKoo Cat#: 465574
Name: QL-X-138
CAS#: unknown
Chemical Formula: C25H19N5O2
Exact Mass: 421.1539
Molecular Weight: 421.46
Elemental Analysis: C, 71.25; H, 4.54; N, 16.62; O, 7.59
The following data is based on the product molecular weight 421.46 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
