MedKoo Cat#: 465569 | Name: FRM-024

Description:

WARNING: This product is for research use only, not for human or veterinary use.

FRM-024 is A Potent CNS-Penetrant Gamma Secretase Modulator. FRM-024 is a GSM preclinical candidate for familial Alzheimer’s disease.

Chemical Structure

FRM-024
FRM-024
CAS#2085780-22-7

Theoretical Analysis

MedKoo Cat#: 465569

Name: FRM-024

CAS#: 2085780-22-7

Chemical Formula: C22H22ClN5O2

Exact Mass: 423.1462

Molecular Weight: 423.90

Elemental Analysis: C, 62.34; H, 5.23; Cl, 8.36; N, 16.52; O, 7.55

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
2085780-22-7 2085780-85-2 (rotation -) 2085780-87-4 (rotation +)
Synonym
FRM-024; FRM024; FRM 024;
IUPAC/Chemical Name
(5R,6S)-5-(4-chlorophenyl)-6-cyclopropyl-3-(6-methoxy-5-(4-methyl-1H-imidazol-1-yl)pyridin-2-yl)-5,6-dihydro-4H-1,2,4-oxadiazine
InChi Key
IOQORVDNYPOZPL-UXHICEINSA-N
InChi Code
InChI=1S/C22H22ClN5O2/c1-13-11-28(12-24-13)18-10-9-17(25-22(18)29-2)21-26-19(14-5-7-16(23)8-6-14)20(30-27-21)15-3-4-15/h5-12,15,19-20H,3-4H2,1-2H3,(H,26,27)/t19-,20+/m1/s1
SMILES Code
CC1=CN(C2=C(OC)N=C(C3=NO[C@@H](C4CC4)[C@@H](C5=CC=C(Cl)C=C5)N3)C=C2)C=N1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 423.90 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Bursavich MG, Harrison BA, Acharya R, Costa DE, Freeman EA, Hrdlicka LA, Jin H, Kapadnis S, Moffit JS, Murphy D, Nolan SJ, Patzke H, Tang C, Van Voorhies HE, Wen M, Koenig G, Blain JF, Burnett DA. Discovery of the Oxadiazine FRM-024: A Potent CNS-Penetrant Gamma Secretase Modulator. J Med Chem. 2021 Sep 22. doi: 10.1021/acs.jmedchem.1c00904. Epub ahead of print. PMID: 34550687.