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MedKoo Cat#: 577430 | Name: Minodronic acid
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Minodronic acid is a biochemical that inhibits osteoclastic bone resorption.

Chemical Structure

Minodronic acid
Minodronic acid
CAS#180064-38-4 (acid),

Theoretical Analysis

MedKoo Cat#: 577430

Name: Minodronic acid

CAS#: 180064-38-4 (acid),

Chemical Formula: C9H12N2O7P2

Exact Mass: 322.0120

Molecular Weight: 322.15

Elemental Analysis: C, 33.56; H, 3.75; N, 8.70; O, 34.76; P, 19.23

Price and Availability

Size Price Availability Quantity
100mg USD 285.00 2 Weeks
250mg USD 550.00 2 Weeks
1g USD 950.00 2 Weeks
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Related CAS #
155648-60-5(monohydrate) 180064-38-4 (acid)
Synonym
Bonoteo; BPH 261; BPH261; BPH-261; Minodronic acid; Recalbon; YM 529; YM529; YM-529
IUPAC/Chemical Name
Phosphonic acid, P,P'-(1-hydroxy-2-imidazo(1,2-a)pyridin-3-ylethylidene)bis-
InChi Key
VMMKGHQPQIEGSQ-UHFFFAOYSA-N
InChi Code
InChI=1S/C9H12N2O7P2/c12-9(19(13,14)15,20(16,17)18)5-7-6-10-8-3-1-2-4-11(7)8/h1-4,6,12H,5H2,(H2,13,14,15)(H2,16,17,18)
SMILES Code
OC(Cc1cnc2ccccn12)(P(=O)(O)O)P(=O)(O)O
Appearance
Solid powder
Purity
>95% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 322.15 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Tanaka M, Mori H, Kawabata K, Mashiba T. Minodronic acid ameliorates vertebral bone strength by increasing bone mineral density in 9-month treatment of ovariectomized cynomolgus monkeys. Bone. 2016 Jul;88:157-64. doi: 10.1016/j.bone.2016.05.001. Epub 2016 May 4. PubMed PMID: 27155564. 2: Kitamura N, Shiraiwa H, Inomata H, Nozaki T, Ikumi N, Sugiyama K, Nagasawa Y, Karasawa H, Iwata M, Matsukawa Y, Takei M. Efficacy and safety of minodronic acid hydrate in patients with steroid-induced osteoporosis. Int J Rheum Dis. 2016 Mar 1. doi: 10.1111/1756-185X.12844. [Epub ahead of print] PubMed PMID: 26929019. 3: Imai A, Matsunami K, Ichigo S, Takagi H. Minodronic acid suppresses gonadotropin-releasing hormone agonist-induced bone remodeling biomarkers: a retrospective pilot study. Gynecol Endocrinol. 2016;32(3):250-2. doi: 10.3109/09513590.2015.1112783. Epub 2015 Nov 20. PubMed PMID: 26503621. 4: Zhou Y, He X, Li H, Ni Y, Xu M, Sattar H, Chen H, Li W. Pharmacokinetics and tolerability of minodronic acid tablets in healthy Chinese subjects and food and age effects on the pharmacokinetics. Clin Ther. 2015 Apr 1;37(4):869-76. doi: 10.1016/j.clinthera.2015.01.015. Epub 2015 Mar 5. PubMed PMID: 25748293. 5: Tanaka M, Matsugaki A, Ishimoto T, Nakano T. Evaluation of crystallographic orientation of biological apatite in vertebral cortical bone in ovariectomized cynomolgus monkeys treated with minodronic acid and alendronate. J Bone Miner Metab. 2016 Mar;34(2):234-41. doi: 10.1007/s00774-015-0658-2. Epub 2015 Apr 3. PubMed PMID: 25837430. 6: Iwamoto J, Seki A, Sato Y. Effect of combined teriparatide and monthly minodronic acid therapy on cancellous bone mass in ovariectomized rats: a bone histomorphometry study. Bone. 2014 Jul;64:88-94. doi: 10.1016/j.bone.2014.04.003. Epub 2014 Apr 13. PubMed PMID: 24727162. 7: Tanaka M, Mori H, Kayasuga R, Ochi Y, Yamada H, Kawada N, Kawabata K. Effect of intermittent and daily regimens of minodronic Acid on bone metabolism in an ovariectomized rat model of osteoporosis. Calcif Tissue Int. 2014 Aug;95(2):166-73. doi: 10.1007/s00223-014-9876-1. Epub 2014 Jun 6. PubMed PMID: 24903232. 8: Yang Y, Liu C, Zhang Y, Zhou L, Zhong D, Chen X. On-cartridge derivatization coupled with solid-phase extraction for the ultra-sensitive determination of minodronic acid in human plasma by LC-MS/MS method. J Pharm Biomed Anal. 2015 Oct 10;114:408-15. doi: 10.1016/j.jpba.2015.05.038. Epub 2015 Jun 18. PubMed PMID: 26117452. 9: Kimoto A, Tanaka M, Nozaki K, Mori M, Fukushima S, Mori H, Shiroya T, Nakamura T. Intermittent minodronic acid treatment with sufficient bone resorption inhibition prevents reduction in bone mass and strength in ovariectomized rats with established osteopenia comparable with daily treatment. Bone. 2013 Jul;55(1):189-97. doi: 10.1016/j.bone.2013.02.013. Epub 2013 Feb 26. PubMed PMID: 23486179. 10: Tanaka M, Mori H, Kawabata K. Attenuation of Antiresorptive Action in Withdrawal of Minodronic Acid for Three Months After Treatment for Twelve Months in Ovariectomized Rats. Calcif Tissue Int. 2015 Oct;97(4):402-11. doi: 10.1007/s00223-015-0017-2. Epub 2015 Jun 6. PubMed PMID: 26048283.

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