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MedKoo Cat#: 465553 | Name: Kongensin D

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Kongensin D is a natural anti-TNBC agent, significantly suppressing the triple-negative breast cancer (TNBC) tumor growth without causing side effects.

Chemical Structure

Kongensin D
Kongensin D
CAS#unknown

Theoretical Analysis

MedKoo Cat#: 465553

Name: Kongensin D

CAS#: unknown

Chemical Formula: C20H28O4

Exact Mass: 332.1988

Molecular Weight: 332.44

Elemental Analysis: C, 72.26; H, 8.49; O, 19.25

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
Kongensin D; Kongensin-D; KongensinD;
IUPAC/Chemical Name
(1R,4aR,6R,10R,13aS,Z)-1,6-dihydroxy-4,4,13a-trimethyl-9-methylene-1,2,3,4,4a,5,6,9,10,11,12,13a-dodecahydro-7,10-(metheno)benzo[11]annulene-8,13-dione
InChi Key
MZEJPAGUQDRCOG-PYMGOFIGSA-N
InChi Code
InChI=1S/C20H28O4/c1-11-12-5-6-16(22)20(4)15(19(2,3)8-7-17(20)23)10-14(21)13(9-12)18(11)24/h9,12,14-15,17,21,23H,1,5-8,10H2,2-4H3/t12-,14-,15-,17-,20-/m1/s1
SMILES Code
O=C1[C@]2(C)[C@H](O)CCC(C)(C)[C@@]2([H])C[C@@H](O)C3=C[C@@](C(C3=O)=C)([H])CC1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 332.44 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Li D, Li C, Li L, Chen S, Wang L, Li Q, Wang X, Lei X, Shen Z. Natural Product Kongensin A is a Non-Canonical HSP90 Inhibitor that Blocks RIP3-dependent Necroptosis. Cell Chem Biol. 2016 Feb 18;23(2):257-266. doi: 10.1016/j.chembiol.2015.08.018. Epub 2016 Jan 28. PMID: 27028885. 2: Bai Y, Lam HC, Lei X. Dissecting Programmed Cell Death with Small Molecules. Acc Chem Res. 2020 May 19;53(5):1034-1045. doi: 10.1021/acs.accounts.9b00600. Epub 2020 Apr 16. PMID: 32297735.