KP-544 | CAS#393856-87-6 | neurotrophin potentiator

MedKoo Cat#: 584345 | Name: KP-544

Description:

WARNING: This product is for research use only, not for human or veterinary use.

KP-544 is a neurotrophin potentiator.

Chemical Structure

KP-544

CAS#393856-87-6

Theoretical Analysis

MedKoo Cat#: 584345

Name: KP-544

CAS#: 393856-87-6

Chemical Formula: C18H19ClN4O

Exact Mass: 342.1247

Molecular Weight: 342.83

Elemental Analysis: C, 63.06; H, 5.59; Cl, 10.34; N, 16.34; O, 4.67

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

KP-544; KP544; KP 544

IUPAC/Chemical Name

2-Amino-5-(4-chlorophenylethynyl)-4-(trans-4-hydroxycyclohexylamino)pyrimidine

InChi Key

XBVOXAWRUIZEMG-WKILWMFISA-N

InChi Code

InChI=1S/C18H19ClN4O/c19-14-5-2-12(3-6-14)1-4-13-11-21-18(20)23-17(13)22-15-7-9-16(24)10-8-15/h2-3,5-6,11,15-16,24H,7-10H2,(H3,20,21,22,23)/t15-,16-

SMILES Code

O[C@H]1CC[C@H](NC2=NC(N)=NC=C2C#CC3=CC=C(Cl)C=C3)CC1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 342.83 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Dey ND, Boersen AJ, Myers RA, York LR, Bombard MC, Lu M, Sandstrom MI, Hulce VD, Lescaudron L, Dunbar GL. The novel substituted pyrimidine, KP544, reduces motor deficits in the R6/2 transgenic mouse model of Huntington's disease. Restor Neurol Neurosci. 2007;25(5-6):485-92. PubMed PMID: 18334766. 2: Geist MA, Volbracht C, Podhorna J, Falsig J, Leist M. Wide spectrum modulation by KP-544 in models relevant for neuronal survival. Neuroreport. 2007 Apr 16;18(6):571-5. PubMed PMID: 17413659.