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MedKoo Cat#: 414970 | Name: Pipazethate HCl

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Pipazethate HCl is a cough suppressant. It is a non-narcotic oral antitussive agent.

Chemical Structure

Pipazethate HCl
Pipazethate HCl
CAS#6056-11-7 (HCl)

Theoretical Analysis

MedKoo Cat#: 414970

Name: Pipazethate HCl

CAS#: 6056-11-7 (HCl)

Chemical Formula: C21H26ClN3O3S

Exact Mass: 0.0000

Molecular Weight: 435.97

Elemental Analysis: C, 57.86; H, 6.01; Cl, 8.13; N, 9.64; O, 11.01; S, 7.35

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Related CAS #
6056-11-7 (HCl); 2167-85-3 (free base)
Synonym
Pipazethate hydrochloride; Pipazethate HCl; NSC 106961; NSC106961; NSC-106961
IUPAC/Chemical Name
10H-Pyrido(3,2-b)(1,4)benzothiazine-10-carboxylic acid, 2-(2-(1-piperidinyl)ethoxy)ethyl ester, monohydrochloride (9CI)
InChi Key
FEUBUXUFKHXRKO-UHFFFAOYSA-N
InChi Code
InChI=1S/C21H25N3O3S.ClH/c25-21(27-16-15-26-14-13-23-11-4-1-5-12-23)24-17-7-2-3-8-18(17)28-19-9-6-10-22-20(19)24;/h2-3,6-10H,1,4-5,11-16H2;1H
SMILES Code
O=C(N1C2=NC=CC=C2SC3=CC=CC=C13)OCCOCCN4CCCCC4.[H]Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 435.97 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Gouda AA, El-Sheikh R, El Shafey Z, Hossny N, El-Azzazy R. Spectrophotometric Determination of Pipazethate HCl and Dextromethorphan HBr using Potassium Permanganate. Int J Biomed Sci. 2008 Dec;4(4):294-302. PubMed PMID: 23675101; PubMed Central PMCID: PMC3614715. 2: Melwanki MB, Seetharamappa J, Masti SP. Spectrophotometric determination of molybdenum(VI) using isothipendyl hydrochloride and pipazethate hydrochloride in alloy steels and soil samples. Anal Sci. 2001 Sep;17(9):1121-3. PubMed PMID: 11708072. 3: Abdel-Ghani NT, Shoukry AF, el Nashar RM. Flow injection potentiometric determination of pipazethate hydrochloride. Analyst. 2001 Jan;126(1):79-85. PubMed PMID: 11205518. 4: Soto E, Ochoa Z, Alvarado H, Espinoza OB, Irastorza IM, Ramirez MS. Pipazethate lethality in a baby. Vet Hum Toxicol. 1993 Feb;35(1):41. PubMed PMID: 8434453. 5: Bonavita V, Crinò C. Accidental lethal pipazethate poisoning in a child. Z Rechtsmed. 1982;89(2):145-8. PubMed PMID: 7180211. 6: Vakil BJ, Mehta AJ, Prajapat KD. Trial of pipazethate as an antitussive. Clin Pharmacol Ther. 1966 Jul-Aug;7(4):515-9. PubMed PMID: 5328471. 7: El-Shiekh R, Amin AS, Zahran F, Gouda AA. Spectrophotometric determination of pipazethate hydrochloride in pure form and in pharmaceutical formulations. J AOAC Int. 2007 May-Jun;90(3):686-92. PubMed PMID: 17580620. 8: Amin AS, El-Sheikh R, Zahran F, Gouda AA. Spectrophotometric determination of pipazethate HCl, dextromethorphan HBr and drotaverine HCl in their pharmaceutical preparations. Spectrochim Acta A Mol Biomol Spectrosc. 2007 Jul;67(3-4):1088-93. Epub 2006 Sep 28. PubMed PMID: 17092767. 9: Issa YM, Shoukry AF, El-Nashar RM. Conductimetric determination of reproterol HCl and pipazethate HCl and salbutamol sulphate in their pharmaceutical formulations. J Pharm Biomed Anal. 2001 Oct;26(3):379-86. PubMed PMID: 11489383. 10: da Silva OA, Lopez M. Pipazethate--acute childhood poisoning. Clin Toxicol. 1977;11(4):455-8. PubMed PMID: 589958. 11: Qualitative and quantitative tests for pipazethate hydrochloride. J Pharm Sci. 1965 Sep;54(9):1338-41. PubMed PMID: 5881232. 12: AMLER AB, ROTHMAN CB. EVALUATION OF PIPAZETHATE AS AN ANTITUSSIVE AGENT IN PEDIATRIC PRACTICE. J New Drugs. 1963 Nov-Dec;3(6):362-6. PubMed PMID: 14113560. 13: BECKLOFF GL, HEWITT MI. THE CLINICAL EVALUATION OF PIPAZETHATE ADMINISTERED RECTALLY IN 172 PEDIATRIC PATIENTS. Am J Med Sci. 1963 Sep;246:285-8. PubMed PMID: 14064876. 14: FISCHMAN ME. Pipazethate suppositories for the suppression of cough in pediatric practice. A report on 61 cases. Arch Pediatr. 1962 Sep;79:332-4. PubMed PMID: 13893186.