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MedKoo Cat#: 599153 | Name: Pinokalant

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Pinokalant is an inhibitor of receptor-activated nonselective cation currents in HL-60 cells.

Chemical Structure

Pinokalant
Pinokalant
CAS#149759-26-2

Theoretical Analysis

MedKoo Cat#: 599153

Name: Pinokalant

CAS#: 149759-26-2

Chemical Formula: C41H48N2O9

Exact Mass: 712.3360

Molecular Weight: 712.84

Elemental Analysis: C, 69.08; H, 6.79; N, 3.93; O, 20.20

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Pinokalant; Loe-908; Loe 908; Loe908;
IUPAC/Chemical Name
2-(6,7-dimethoxy-3,4-dihydroisoquinolin-1-yl)-2-phenyl-N,N-bis(2,3,4-trimethoxyphenethyl)acetamide
InChi Key
PYWYBTRACMRUQV-UHFFFAOYSA-N
InChi Code
InChI=1S/C41H48N2O9/c1-45-31-16-14-27(37(49-5)39(31)51-7)19-22-43(23-20-28-15-17-32(46-2)40(52-8)38(28)50-6)41(44)35(26-12-10-9-11-13-26)36-30-25-34(48-4)33(47-3)24-29(30)18-21-42-36/h9-17,24-25,35H,18-23H2,1-8H3
SMILES Code
O=C(N(CCC1=CC=C(OC)C(OC)=C1OC)CCC2=CC=C(OC)C(OC)=C2OC)C(C3=CC=CC=C3)C4=NCCC5=C4C=C(OC)C(OC)=C5
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 712.84 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Christensen T, Wienrich M, Ensinger HA, Diemer NH. The broad-spectrum cation channel blocker pinokalant (LOE 908 MS) reduces brain infarct volume in rats: a temperature-controlled histological study. Basic Clin Pharmacol Toxicol. 2005 Apr;96(4):316-24. PubMed PMID: 15755315. 2: Leusch A, Eichhorn B, Busch U, Ensinger HA. Pharmacokinetics of pinokalant, a new nonselective cation channel blocker in the rat. Arzneimittelforschung. 2001;51(12):947-54. PubMed PMID: 11799840. 3: Simard JM, Tarasov KV, Gerzanich V. Non-selective cation channels, transient receptor potential channels and ischemic stroke. Biochim Biophys Acta. 2007 Aug;1772(8):947-57. Epub 2007 Mar 19. Review. PubMed PMID: 17446049; PubMed Central PMCID: PMC1986778.