MedKoo Cat#: 414915 | Name: Phenpromethamine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Phenpromethamine is a sympathomimetic agent structurally related to amphetamines. It primarily acts as a central nervous system stimulant, though detailed pharmacological data are scarce due to its limited clinical use and historical classification as an anorectic. In early pharmacological studies, Phenpromethamine was shown to increase locomotor activity in rodents and elevate blood pressure in animal models, suggesting potent adrenergic activity.

Chemical Structure

Phenpromethamine
Phenpromethamine
CAS#93-88-9 (free base)

Theoretical Analysis

MedKoo Cat#: 414915

Name: Phenpromethamine

CAS#: 93-88-9 (free base)

Chemical Formula: C10H15N

Exact Mass: 149.1204

Molecular Weight: 149.24

Elemental Analysis: C, 80.48; H, 10.13; N, 9.39

Price and Availability

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Synonym
Phenpromethamine; Phenylpropylmethylamine; Vonedrine; Benzedrine; β,N-MePEA;
IUPAC/Chemical Name
Benzeneethanamine, N,beta-dimethyl- (9CI)
InChi Key
AUFSOOYCQYDGES-UHFFFAOYSA-N
InChi Code
InChI=1S/C10H15N/c1-9(8-11-2)10-6-4-3-5-7-10/h3-7,9,11H,8H2,1-2H3
SMILES Code
CC(C1=CC=CC=C1)CNC
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 149.24 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Lisi A, Hasick N, Kazlauskas R, Goebel C. Studies of methylhexaneamine in supplements and geranium oil. Drug Test Anal. 2011 Nov-Dec;3(11-12):873-6. doi: 10.1002/dta.392. Epub 2011 Dec 6. PMID: 22147493. 2: Cohen PA, Travis JC, Vanhee C, Ohana D, Venhuis BJ. Nine prohibited stimulants found in sports and weight loss supplements: deterenol, phenpromethamine (Vonedrine), oxilofrine, octodrine, beta-methylphenylethylamine (BMPEA), 1,3-dimethylamylamine (1,3-DMAA), 1,4-dimethylamylamine (1,4-DMAA), 1,3-dimethylbutylamine (1,3-DMBA) and higenamine. Clin Toxicol (Phila). 2021 Mar 23:1-7. doi: 10.1080/15563650.2021.1894333. Epub ahead of print. PMID: 33755516. 3: Liu Y, Santillo MF. Cytochrome P450 2D6 and 3A4 enzyme inhibition by amine stimulants in dietary supplements. Drug Test Anal. 2016 Mar-Apr;8(3-4):307-10. doi: 10.1002/dta.1863. Epub 2015 Sep 11. PMID: 26360628. 4: Zhang TT, Huang Y, Zhang XJ, Chen J, Hua ZD. Structure Analysis of the Interfering Substance N-methyl-2-phenylpropan-1-amine of Methamphetamine in Wastewater. Fa Yi Xue Za Zhi. 2022 Dec 25;38(6):726-732. English, Chinese. doi: 10.12116/j.issn.1004-5619.2022.320102. PMID: 36914388.