ARN16186 is a potent rat NAAA inhibitor. Preventive chronic treatment with ARN16186 was efficacious in slowing disease progression and preserving locomotor activity in EAE mice. Furthermore, NAAA inhibition reduced the number of immune cells infiltrating the spinal cord and modulated the overactivation of NF-kB and STAT3 transcription factors, leading to less expansion of Th17 cells over the course of the disease. Note: Sci-finder mistakenly listed CAS#2840633-45-4 for ARN16186 ( in which the pyrazol-ring is hully reduced). The correct structure is listed in https://www.sciencedirect.com/science/article/abs/pii/S104366182100400X.
MedKoo Cat#: 465462
Name: ARN16186
CAS#: 2320555-85-7
Chemical Formula: C22H31N3O3S
Exact Mass: 417.2086
Molecular Weight: 417.57
Elemental Analysis: C, 63.28; H, 7.48; N, 10.06; O, 11.49; S, 7.68
The following data is based on the product molecular weight 417.57 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
