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MedKoo Cat#: 577382 | Name: Metyrapone hydrochloride

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Metyrapone hydrochloride is a biochemical that blocks cortisol synthesis by reversibly inhibiting steroid 11β-hydroxylase.

Chemical Structure

Metyrapone hydrochloride
Metyrapone hydrochloride
CAS#22752-91-6

Theoretical Analysis

MedKoo Cat#: 577382

Name: Metyrapone hydrochloride

CAS#: 22752-91-6

Chemical Formula: C14H15ClN2O

Exact Mass: 262.0873

Molecular Weight: 262.74

Elemental Analysis: C, 64.00; H, 5.75; Cl, 13.49; N, 10.66; O, 6.09

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Metyrapone hydrochloride; Metyrapone HCl
IUPAC/Chemical Name
1-Propanone, 2-methyl-1,2-di-3-pyridinyl-, hydrochloride
InChi Key
NLEWDSPHLFJEJR-UHFFFAOYSA-N
InChi Code
InChI=1S/C14H14N2O.ClH/c1-14(2,12-6-4-8-16-10-12)13(17)11-5-3-7-15-9-11;/h3-10H,1-2H3;1H
SMILES Code
Cl.CC(C)(C(=O)c1cccnc1)c2cccnc2
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 262.74 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Ferrier IN, Anderson IM, Barnes J, Gallagher P, Grunze HCR, Haddad PM, House AO, Hughes T, Lloyd AJ, Mamasoula C, McColl E, Pearce S, Siddiqi N, Sinha B, Speed C, Steen N, Wainwright J, Watson S, Winter FH, McAllister-Williams RH. Randomised controlled trial of Antiglucocorticoid augmentation (metyrapone) of antiDepressants in Depression (ADD Study). Southampton (UK): NIHR Journals Library; 2015 Jun. PubMed PMID: 26086063. 2: Goeders NE, Guerin GF, Schmoutz CD. The combination of metyrapone and oxazepam for the treatment of cocaine and other drug addictions. Adv Pharmacol. 2014;69:419-79. doi: 10.1016/B978-0-12-420118-7.00011-1. Review. PubMed PMID: 24484984. 3: Hána V, Dokoupilová M, Marek J, Plavka R. Recurrent ACTH-independent Cushing's syndrome in multiple pregnancies and its treatment with metyrapone. Clin Endocrinol (Oxf). 2001 Feb;54(2):277-81. Review. PubMed PMID: 11207645. 4: Tanaka K, Toriumi M, Itoh S, Ogino Y. [Metyrapone test]. Nihon Rinsho. 1997 Apr;55 Suppl 2:349-52. Review. Japanese. PubMed PMID: 9172545. 5: Hildebrandt AG. The binding of metyrapone to cytochrome P-450 and its inhibitory action on microsomal hepatic mixed function oxidation reactions. Biochem Soc Symp. 1972;34:79-102. Review. PubMed PMID: 4570969.