FPPQ is a Dual-Acting 5‑HT3 (K1 = 0.9 nM) and 5‑HT6 (Ki = 3 nM) Receptor Antagonist with Antipsychotic and Procognitive Properties. FPPQ behaves as a 5-HT3R antagonist and a neutral antagonist 5-HT6R of the Gs pathway. FPPQ shows selectivity over 87 targets and decent brain penetration. Likewise, FPPQ inhibits phencyclidine (PCP)-induced hyperactivity and displays procognitive properties in the novel object recognition task.
MedKoo Cat#: 465458
Name: FPPQ
CAS#: unknown
Chemical Formula: C21H19FN4O2S
Exact Mass: 410.1213
Molecular Weight: 410.47
Elemental Analysis: C, 61.45; H, 4.67; F, 4.63; N, 13.65; O, 7.80; S, 7.81
The following data is based on the product molecular weight 410.47 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
