MedKoo Cat#: 414861 | Name: Perimetazine HCl
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Perimetazine HCl is a phenothiazine used to treat or prevent nausea and vomiting caused by anesthesia or surgery, certain types of allergic reactions, pain caused by surgery or childbirth, and to sedate patients before surgery or medical procedures.

Chemical Structure

Perimetazine HCl
CAS#58-33-3 (HCl)

Theoretical Analysis

MedKoo Cat#: 414861

Name: Perimetazine HCl

CAS#: 58-33-3 (HCl)

Chemical Formula: C22H29ClN2O2S

Exact Mass: 420.1638

Molecular Weight: 420.99

Elemental Analysis: C, 62.77; H, 6.94; Cl, 8.42; N, 6.65; O, 7.60; S, 7.62

Price and Availability

Size Price Availability Quantity
25g USD 350.00 2 Weeks
100g USD 750.00 2 Weeks
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Related CAS #
58-33-3 (HCl); 13093-88-4 (free base)
Synonym
Perimetazine hydrochloride; Perimetazine HCl; AN1317 hydrochloride; AN-1317 hydrochloride; AN 1317 hydrochloride
IUPAC/Chemical Name
4-Piperidinol, 1-(3-(2-methoxyphenothiazin-10-yl)-2-methylpropyl)-, hydrochloride
InChi Key
ZJHKNVKSHYILFM-UHFFFAOYSA-N
InChi Code
InChI=1S/C22H28N2O2S.ClH/c1-16(14-23-11-9-17(25)10-12-23)15-24-19-5-3-4-6-21(19)27-22-8-7-18(26-2)13-20(22)24;/h3-8,13,16-17,25H,9-12,14-15H2,1-2H3;1H
SMILES Code
OC1CCN(CC(C)CN2C3=C(C=CC=C3)SC4=CC=C(OC)C=C24)CC1.[H]Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 420.99 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Ikeda S, Murayama S. [Neuropharmacological studies of perimetazine]. Nihon Yakurigaku Zasshi. 1976;72(1):113-26. Japanese. PubMed PMID: 986345. 2: Naito J, Kuga T. [Pharmacological analysis of effects of perimetazine on isolated smooth muscle]. Nihon Yakurigaku Zasshi. 1976 Nov;72(8):1013-23. Japanese. PubMed PMID: 14870. 3: Volle L, Baudinot J, Lardet C, Frairot A. [Study of a new neuroleptic in a department of general medicine of adults: perimetazine (1317 A.N.)]. Lyon Med. 1970 May 24;223(21):1083-6. French. PubMed PMID: 5421811. 4: Rainaut J. [Study of 1317-A.N., Leptryl. Possibilities in psychiatric treatment with a new phenothiazine: perimetazine or 1317 A.N]. Mars Med. 1970;107(4):353-61. French. PubMed PMID: 4912083. 5: Kappas A. On the mechanisms of induced aneuploidy in Aspergillus nidulans and validation of tests for genomic mutations. Prog Clin Biol Res. 1989;318:377-84. PubMed PMID: 2696976. 6: Picard JM, Pagnon F, Helmer J, Henry A. [Perimetazin in cardiac surgery with extracorporeal circulation]. Anesth Analg (Paris). 1972 May-Jun;29(3):395-9. French. PubMed PMID: 4405448. 7: Bourgeois M, Sicart AM. [Trial of perimethazine, A. N. 1317 or R. P. 9159 (Leptril) in psychiatry]. Bord Med. 1970 Feb;3(2):515-22. French. PubMed PMID: 5425878.