Related CAS #
546-48-5 (tartrate); 79-55-0 (free base); 6152-95-0 (HCl)
Synonym
Pempidine tartrate; Sinapleg; Synapleg
IUPAC/Chemical Name
Piperidine, 1,2,2,6,6-pentamethyl-, (R-(R*,R*))-2,3-dihydroxybutanedioate (1:1) (9CI)
InChi Key
AAFNEINEQRQMTF-LREBCSMRSA-N
InChi Code
InChI=1S/C10H21N.C4H6O6/c1-9(2)7-6-8-10(3,4)11(9)5;5-1(3(7)8)2(6)4(9)10/h6-8H2,1-5H3;1-2,5-6H,(H,7,8)(H,9,10)/t;1-,2-/m.1/s1
SMILES Code
CC1(C)CCCC(C)(C)N1C.O=C(O)[C@H](O)[C@@H](O)C(O)=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
305.37
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Somers K. Pempidine for Hypertension. Br Med J. 1961 Jan 7;1(5218):13-5. doi: 10.1136/bmj.1.5218.13. PMID: 20789025; PMCID: PMC1952734.
2: Martin TJ, Suchocki J, May EL, Martin BR. Pharmacological evaluation of the antagonism of nicotine's central effects by mecamylamine and pempidine. J Pharmacol Exp Ther. 1990 Jul;254(1):45-51. PMID: 2366189.
3: DOLLERY CT, EMSLIE-SMITH D, MUGGLETON DF. Action of chlorothiazide on the distribution excretion and hypotensive effect of pempidine in man. Br J Pharmacol Chemother. 1961 Dec;17(3):488-506. doi: 10.1111/j.1476-5381.1961.tb01136.x. PMID: 13887050; PMCID: PMC1482097.
4: MUGGLETON DF, READING HW. Absorption, metabolism and elimination of pempidine in the rat. Br J Pharmacol Chemother. 1959 Jun;14(2):202-8. doi: 10.1111/j.1476-5381.1959.tb01384.x. PMID: 13662574; PMCID: PMC1481796.
5: HOUSTON IB, SEARS HT. Comparison of trimethidinium and pempidine in treatment of severe hypertension. Br Med J. 1960 Feb 20;1(5172):518-20. doi: 10.1136/bmj.1.5172.518. PMID: 14403415; PMCID: PMC1966530.
6: DHAWAN KN, BHARGAVA KP. Central vasomotor effects of a new ganglion-blocking agent--1: 2: 2: 6: 6-pentamethyl piperidine (pempidine). Br J Pharmacol Chemother. 1960 Jun;15(2):215-8. doi: 10.1111/j.1476-5381.1960.tb01233.x. PMID: 13848257; PMCID: PMC1481938.
7: BLACKMAN JG, RAY C. ACTIONS OF MECAMYLAMINE, DIMECAMINE, PEMPIDINE AND THEIR TWO QUATERNARY METHO-SALTS AT THE NEUROMUSCULAR JUNCTION. Br J Pharmacol Chemother. 1964 Feb;22(1):56-65. doi: 10.1111/j.1476-5381.1964.tb01543.x. PMID: 14126057; PMCID: PMC1703911.
8: SPINKS A, YOUNG EH, FARRINGTON JA, DUNLOP D. The pharmacological actions of pempidine and its ethyl homologue. Br J Pharmacol Chemother. 1958 Dec;13(4):501-20. doi: 10.1111/j.1476-5381.1958.tb00246.x. PMID: 13618559; PMCID: PMC1481871.
9: BURN JH, GIBBONS WR. THE ACTION OF MECAMYLAMINE AND OF PEMPIDINE. Lancet. 1964 Feb 22;1(7330):414-5. doi: 10.1016/s0140-6736(64)92791-6. PMID: 14092959.
10: BRETHERICK L, LEE GE, LUNT E, WRAGG WR, EDGE ND. Congeners of pempidine with high ganglion-blocking activity. Nature. 1959 Nov 28;184(Suppl 22):1707-9. doi: 10.1038/1841707a0. PMID: 13804263.
