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MedKoo Cat#: 577332 | Name: Prednisolone sodium succinate

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Prednisolone sodium succinate is a glucocorticoid with anti-inflammatory and immunosuppressive activity.

Chemical Structure

Prednisolone sodium succinate
CAS#1715-33-9

Theoretical Analysis

MedKoo Cat#: 577332

Name: Prednisolone sodium succinate

CAS#: 1715-33-9

Chemical Formula: C25H31NaO8

Exact Mass: 482.1917

Molecular Weight: 482.50

Elemental Analysis: C, 62.23; H, 6.48; Na, 4.76; O, 26.53

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Prednisolone sodium succinate
IUPAC/Chemical Name
Pregna-1,4-diene-3,20-dione, 11-beta,17,21-trihydroxy-, 21-(hydrogen succinate), monosodium salt
InChi Key
FKKAEMQFOIDZNY-CODXZCKSSA-M
InChi Code
InChI=1S/C25H32O8.Na/c1-23-9-7-15(26)11-14(23)3-4-16-17-8-10-25(32,24(17,2)12-18(27)22(16)23)19(28)13-33-21(31)6-5-20(29)30;/h7,9,11,16-18,22,27,32H,3-6,8,10,12-13H2,1-2H3,(H,29,30);/q;+1/p-1/t16-,17-,18-,22+,23-,24-,25-;/m0./s1
SMILES Code
[Na+].C[C@]12C[C@H](O)[C@H]3[C@@H](CCC4=CC(=O)C=C[C@]34C)[C@@H]1CC[C@]2(O)C(=O)COC(=O)CCC(=O)[O-]
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 482.50 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Hayashi S, Akao N, Okamoto K. Meningeal plasma cell granuloma in the early stage of relapsing polychondritis. Rinsho Shinkeigaku. 2017 May 26. doi: 10.5692/clinicalneurol.cn-000975. [Epub ahead of print] PubMed PMID: 28552866. 2: Nived P, Nagel J, Saxne T, Geborek P, Jönsson G, Skattum L, Kapetanovic MC. Immune response to pneumococcal conjugate vaccine in patients with systemic vasculitis receiving standard of care therapy. Vaccine. 2017 May 25. pii: S0264-410X(17)30680-1. doi: 10.1016/j.vaccine.2017.05.044. [Epub ahead of print] PubMed PMID: 28552512. 3: Padberg S, Mick I, Frenzel C, Greil R, Hilberath J, Schaefer C. Transient congenital dilated cardiomyopathy after maternal R-CHOP chemotherapy during pregnancy. Reprod Toxicol. 2017 May 24. pii: S0890-6238(16)30498-1. doi: 10.1016/j.reprotox.2017.05.008. [Epub ahead of print] PubMed PMID: 28552383. 4: van der Aa NE, Grotenhuis HB, Breur HJM. Remarkable improvement in mitral valve regurgitation in paediatric eosinophilic granuloma with polyangiitis. Cardiol Young. 2017 May 29:1-3. doi: 10.1017/S1047951117000889. [Epub ahead of print] PubMed PMID: 28552076. 5: Kawazoe M, Kaneko K, Shikano K, Kusunoki N, Nanki T, Kawai S. Glucocorticoid therapy causes contradictory changes of serum Wnt signaling-related molecules in systemic autoimmune diseases. Clin Rheumatol. 2017 May 27. doi: 10.1007/s10067-017-3689-3. [Epub ahead of print] PubMed PMID: 28551822. 6: Sylvester B, Porfire A, Van Bockstal PJ, Porav S, Achim M, Beer T, Tomuță I. Formulation Optimization of Freeze-Dried Long-Circulating Liposomes and In-Line Monitoring of the Freeze-Drying Process using an NIR Spectroscopy Tool. J Pharm Sci. 2017 May 24. pii: S0022-3549(17)30381-7. doi: 10.1016/j.xphs.2017.05.024. [Epub ahead of print] PubMed PMID: 28551424. 7: Serra SS, Pedrosa T, Falcão S, Branco JC. [Severe Interstitial Lung Disease and Manic Symptoms Secondary to Corticosteroids in a Patient with Systemic Lupus Erythematosus and Secondary Sjögren's Syndrome]. Acta Med Port. 2017 Mar 31;30(3):246-250. doi: 10.20344/amp.7297. Epub 2017 Mar 31. Portuguese. PubMed PMID: 28550835. 8: Mu X, Tang Y, Takayama K, Chen W, Lu A, Wang B, Weiss K, Huard J. RhoA/Rock Inhibition Improves the Beneficial Effects of Glucocorticoid Treatment in Dystrophic Muscle: Implications for Stem Cell Depletion. Hum Mol Genet. 2017 May 26. doi: 10.1093/hmg/ddx117. [Epub ahead of print] PubMed PMID: 28549178. 9: Karras A, Pagnoux C, Haubitz M, Groot K, Puechal X, Tervaert JWC, Segelmark M, Guillevin L, Jayne D; European Vasculitis Society.. Randomised controlled trial of prolonged treatment in the remission phase of ANCA-associated vasculitis. Ann Rheum Dis. 2017 May 25. pii: annrheumdis-2017-211123. doi: 10.1136/annrheumdis-2017-211123. [Epub ahead of print] PubMed PMID: 28546260. 10: Weckmann M, Becker T, Nissen G, Pech M, Kopp MV. SiMA: A simplified migration assay for analyzing neutrophil migration. Cytometry A. 2017 May 19. doi: 10.1002/cyto.a.23114. [Epub ahead of print] PubMed PMID: 28544679. 11: Workman AD, Carey RM, Kohanski MA, Adappa ND, Palmer JN, Cohen NA. Effects of ophthalmologic solutions on sinonasal ciliated epithelium. Int Forum Allergy Rhinol. 2017 May 23. doi: 10.1002/alr.21953. [Epub ahead of print] PubMed PMID: 28544585. 12: Georgakopoulou EA, Achtari MD. Oral lichenoid lesions of the upper lip. J Dermatol Case Rep. 2017 Mar 31;11(1):16-19. doi: 10.3315/jdcr.2017.1243. eCollection 2017 Mar 31. PubMed PMID: 28539985; PubMed Central PMCID: PMC5439692. 13: Saito A, Takeuchi Y, Kagaya S, Ojima Y, Fukami H, Sato H, Matsuda K, Nagasawa T. Remission Induction Therapy with Rituximab for Microscopic Polyangiitis: A Feasibility Study. Tohoku J Exp Med. 2017;242(1):53-62. doi: 10.1620/tjem.242.53. PubMed PMID: 28539536. 14: Kono M, Hasegawa T, Nagai S, Odani T, Akikawa K, Nomura Y, Sato H, Kikuchi K, Amizuka N, Kikuchi H. Palisaded neutrophilic and granulomatous dermatitis as a novel cause of hypercalcemia: A case report. Medicine (Baltimore). 2017 May;96(21):e6968. doi: 10.1097/MD.0000000000006968. PubMed PMID: 28538395. 15: Nagai N, Ibuki M, Shinoda H, Kameyama K, Tsubota K, Ozawa Y. Maculopapular rash after intravitreal injection of an antivascular endothelial growth factor, aflibercept, for treating age-related macular degeneration: A case report. Medicine (Baltimore). 2017 May;96(21):e6965. doi: 10.1097/MD.0000000000006965. PubMed PMID: 28538392. 16: Coler-Reilly ALG, Sato T, Matsuzaki T, Nakagawa M, Niino M, Nagai M, Nakamura T, Takenouchi N, Araya N, Yagishita N, Inoue E, Yamano Y. Effectiveness of Daily Prednisolone to Slow Progression of Human T-Lymphotropic Virus Type 1-Associated Myelopathy/Tropical Spastic Paraparesis: A Multicenter Retrospective Cohort Study. Neurotherapeutics. 2017 May 23. doi: 10.1007/s13311-017-0533-z. [Epub ahead of print] PubMed PMID: 28536850. 17: Chun BY, Kim SY. Acute visual loss after botulinum toxin A injection in the masseter muscle. Int Ophthalmol. 2017 May 23. doi: 10.1007/s10792-017-0569-4. [Epub ahead of print] PubMed PMID: 28536763. 18: Finlay JR, Wyatt K, North C. Recovery from Cyclophosphamide Overdose in a Dog. J Am Anim Hosp Assoc. 2017 May 23. doi: 10.5326/JAAHA-MS-6411. [Epub ahead of print] PubMed PMID: 28535135. 19: Lau ETL, Johnson SK, Williams BA, Mikkelsen D, McCourt E, Stanley RA, Mereddy R, Halley PJ, Steadman KJ. Optimizing Prednisolone Loading into Distiller's Dried Grain Kafirin Microparticles, and In vitro Release for Oral Delivery. Pharmaceutics. 2017 May 19;9(2). pii: E17. doi: 10.3390/pharmaceutics9020017. PubMed PMID: 28534827. 20: Lin WT, Chen YM, Chen DY, Lan JL, Chang CS, Yeh HZ, Yang SS. Increased risk of hepatitis B virus reactivation in systemic lupus erythematosus patients receiving immunosuppressants: a retrospective cohort study. Lupus. 2017 Jan 1:961203317711009. doi: 10.1177/0961203317711009. [Epub ahead of print] PubMed PMID: 28534427.

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