Synonym
MDL27088; MDL 27088; MDL-27088
IUPAC/Chemical Name
Pyrido(2,1-a)(2)benzazepine-4-carboxylic acid, 7-((1-carboxy-3-phenylpropyl)amino)-1,2,3,4,6,7,8,12a-octahydro-6-oxo-, (4S-(4alpha,7alpha(R*),12bbeta))-
InChi Key
MFPBDCIKVMSRDU-KJJMTIBFSA-N
InChi Code
InChI=1S/C25H28N2O5/c28-23-20(26-19(24(29)30)14-13-16-7-2-1-3-8-16)15-17-9-4-5-10-18(17)21-11-6-12-22(25(31)32)27(21)23/h1-5,7-10,19-22,26H,6,11-15H2,(H,29,30)(H,31,32)/t19-,20-,21+,22-/m0/s1
SMILES Code
OC(=O)[C@H](CCc1ccccc1)N[C@H]2Cc3ccccc3[C@H]4CCC[C@H](N4C2=O)C(=O)O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
438.52
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1. Stuhler JD, Cheng H, Dorrbecker BR. Disposition of a new diacid angiotensin-converting enzyme inhibitor after intravenous administration of drug or prodrug to monkeys and dogs. J Pharm Sci. 1992 Nov;81(11):1071-3. doi: 10.1002/jps.2600811105. PMID: 1447706.
2. Cheng H, Stuhler JD, Dorrbecker BR, Gordon WP. Disposition and metabolism of the angiotensin-converting enzyme inhibitor [4S-[4 alpha, 7 alpha, (R*), 12b beta]]-7-[S-(1-ethoxycarbonyl-3- phenylpropyl)amino]-1,2,3,4,6,7,8,12b-octahydro-6-oxo- pyrido[2,1-a][2]benzazepine-4-carboxylic acid in monkeys and dogs. Drug Metab Dispos. 1991 Jan-Feb;19(1):212-7. PMID: 1673401.
3. Giroux E, Beight DW, Dage RC, Flynn GA. Interaction of angiotensin I-converting enzyme with two potent tricyclic inhibitors. J Enzyme Inhib. 1989;2(4):269-77. doi: 10.3109/14756368909088480. PMID: 2542490.
