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MedKoo Cat#: 577313 | Name: Methopromazine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Methopromazine is a derivative of phenothiazine.

Chemical Structure

Methopromazine
Methopromazine
CAS#61-01-8

Theoretical Analysis

MedKoo Cat#: 577313

Name: Methopromazine

CAS#: 61-01-8

Chemical Formula: C18H22N2OS

Exact Mass: 314.1453

Molecular Weight: 314.45

Elemental Analysis: C, 68.75; H, 7.05; N, 8.91; O, 5.09; S, 10.20

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Methopromazine; Neoproma; RP 4632; RP4632; RP-4632; Tenton; Tentone
IUPAC/Chemical Name
Phenothiazine, 10-(3-(dimethylamino)propyl)-2-methoxy
InChi Key
BRABPYPSZVCCLR-UHFFFAOYSA-N
InChi Code
InChI=1S/C18H22N2OS/c1-19(2)11-6-12-20-15-7-4-5-8-17(15)22-18-10-9-14(21-3)13-16(18)20/h4-5,7-10,13H,6,11-12H2,1-3H3
SMILES Code
COc1ccc2Sc3ccccc3N(CCCN(C)C)c2c1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Toxicity Data: Mouse - LD50, Intraperitoneal (112mg/kg) - Effects: Respiratory Depression Mouse - LD50, Oral (408mg/kg) - Effects: Respiratory Depression Rat - LD50, Intraperitoneal (95mg/kg) - Effects: Respiratory Depression Rat - LD50, Oral (730mg/kg) - Effects: Respiratory Depression Source: Archives Internationales de Pharmacodynamie et de Therapie. Vol. 125, Pg. 101, 1960. Melting Point: 44-48 deg C pKa Dissociation Constant: 9.3 log P (octanol-water): 4.9 Water Solubility: ~0.522 mg/L Vapor Pressure: ~1.24E-07 mm Hg

Preparing Stock Solutions

The following data is based on the product molecular weight 314.45 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. CAHN J, GEORGES G, PIERRE R. Etude pharmacologique d'un nouveau dérivé de la phénothiazine, le 4632 RP ou méthopromazine [Pharmacological study of a new derivative of phenothiazine, 4632 RP or methopromazine]. C R Seances Soc Biol Fil. 1957;151(12):2082-4. French. PMID: 13585712. 2. JOURDAN F, DUCHENE-MARULLAZ P, FAUCON G, BOUVEROT P. Experimental study on the effect of methopromazine on the cardiovascular & autonomic nervous systems. Arch Int Pharmacodyn Ther. 1958 Nov-Dec;117(3-4):341-63. English, French. PMID: 13606944. 3. JOURDAN F, DUCHENE-MARULLAZ P, FAUCON G, BOUVEROT P. Methopromazine, cardiovascular apparatus and autonomic nervous system. C R Seances Soc Biol Fil. 1958;152(1):91-3. English, French. PMID: 13597175.