K-25a | CAS#unknown | NNRT inhibitor

MedKoo Cat#: 465422 | Name: K-25a

Description:

WARNING: This product is for research use only, not for human or veterinary use.

K-25a is a non-nucleoside reverse Transcriptase inhibitor (NNRTI).

Chemical Structure

K-25a

CAS#unknown

Theoretical Analysis

MedKoo Cat#: 465422

Name: K-25a

CAS#: unknown

Chemical Formula: C29H30N6O3S2

Exact Mass: 574.1821

Molecular Weight: 574.72

Elemental Analysis: C, 60.61; H, 5.26; N, 14.62; O, 8.35; S, 11.16

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

K-25a; K25a; K 25a;

IUPAC/Chemical Name

(E)-4-((4-((4-(4-(2-cyanovinyl)-2,6-dimethylphenoxy)thieno[3,2-d]pyrimidin-2-yl)amino)piperidin-1-yl)methyl)benzenesulfonamide

InChi Key

GVCHBMCBPBRORW-ONEGZZNKSA-N

InChi Code

InChI=1S/C29H30N6O3S2/c1-19-16-22(4-3-12-30)17-20(2)26(19)38-28-27-25(11-15-39-27)33-29(34-28)32-23-9-13-35(14-10-23)18-21-5-7-24(8-6-21)40(31,36)37/h3-8,11,15-17,23H,9-10,13-14,18H2,1-2H3,(H2,31,36,37)(H,32,33,34)/b4-3+

SMILES Code

CC1=CC(/C=C/C#N)=CC(C)=C1OC2=C(SC=C3)C3=NC(NC4CCN(CC5=CC=C(S(=O)(N)=O)C=C5)CC4)=N2

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 574.72 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Renner N, Mallery DL, Faysal KMR, Peng W, Jacques DA, Böcking T, James LC. A lysine ring in HIV capsid pores coordinates IP6 to drive mature capsid assembly. PLoS Pathog. 2021 Feb 1;17(2):e1009164. doi: 10.1371/journal.ppat.1009164. PMID: 33524070; PMCID: PMC7850482. 2: Stansell E, Apkarian R, Haubova S, Diehl WE, Tytler EM, Hunter E. Basic residues in the Mason-Pfizer monkey virus gag matrix domain regulate intracellular trafficking and capsid-membrane interactions. J Virol. 2007 Sep;81(17):8977-88. doi: 10.1128/JVI.00657-07. Epub 2007 Jun 27. PMID: 17596311; PMCID: PMC1951391. 3: Martins A, Shuman S. Mutational analysis of baculovirus phosphatase identifies structural residues important for triphosphatase activity in vitro and in vivo. Biochemistry. 2002 Nov 12;41(45):13403-9. doi: 10.1021/bi0265426. PMID: 12416985.