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MedKoo Cat#: 414798 | Name: Pca 4248

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Pca 4248 is a platelet activating factor antagonist. Treatment with Pca 4248 resulted in a significant increase of macrophage infection in a concentration-dependent manner,

Chemical Structure

Pca 4248
Pca 4248
CAS#123875-01-4

Theoretical Analysis

MedKoo Cat#: 414798

Name: Pca 4248

CAS#: 123875-01-4

Chemical Formula: C19H23NO4S

Exact Mass: 361.1348

Molecular Weight: 361.46

Elemental Analysis: C, 63.14; H, 6.41; N, 3.88; O, 17.71; S, 8.87

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Pca 4248; Pca4248; Pca-4248
IUPAC/Chemical Name
3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,4,6-trimethyl-, methyl 2-(phenylthio)ethyl ester
InChi Key
DHCNAWNKZMNTIS-UHFFFAOYSA-N
InChi Code
InChI=1S/C19H23NO4S/c1-12-16(18(21)23-4)13(2)20-14(3)17(12)19(22)24-10-11-25-15-8-6-5-7-9-15/h5-9,12,20H,10-11H2,1-4H3
SMILES Code
O=C(C1=C(C)NC(C)=C(C(OCCSC2=CC=CC=C2)=O)C1C)OC
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 361.46 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Briones MRS, Snyder AM, Ferreira RC, Neely EB, Connor JR, Broach JR. A Possible Role for Platelet-Activating Factor Receptor in Amyotrophic Lateral Sclerosis Treatment. Front Neurol. 2018 Feb 6;9:39. doi: 10.3389/fneur.2018.00039. PMID: 29472887; PMCID: PMC5810282. 2: Borges AF, Morato CI, Gomes RS, Dorta ML, de Oliveira MAP, Ribeiro-Dias F. Platelet-activating factor increases reactive oxygen species-mediated microbicidal activity of human macrophages infected with Leishmania (Viannia) braziliensis. Pathog Dis. 2017 Sep 29;75(7). doi: 10.1093/femspd/ftx082. PMID: 28830073. 3: Wang HF, Jia HZ, Chu YF, Feng J, Zhang XZ, Zhuo RX. Acidity-promoted cellular uptake and drug release mediated by amine-functionalized block polycarbonates prepared via one-shot ring-opening copolymerization. Macromol Biosci. 2014 Apr;14(4):526-36. doi: 10.1002/mabi.201300414. Epub 2013 Nov 25. PMID: 24273081. 4: Guerrero AT, Zarpelon AC, Vieira SM, Pinto LG, Ferreira SH, Cunha FQ, Verri WA Jr, Cunha TM. The role of PAF/PAFR signaling in zymosan-induced articular inflammatory hyperalgesia. Naunyn Schmiedebergs Arch Pharmacol. 2013 Jan;386(1):51-9. doi: 10.1007/s00210-012-0813-4. Epub 2012 Nov 28. Erratum in: Naunyn Schmiedebergs Arch Pharmacol. 2013 Apr;386(4):351. Zaperlon, Ana C [corrected to Zarpelon, Ana C]. PMID: 23187752. 5: Singh TP, Huettner B, Koefeler H, Mayer G, Bambach I, Wallbrecht K, Schön MP, Wolf P. Platelet-activating factor blockade inhibits the T-helper type 17 cell pathway and suppresses psoriasis-like skin disease in K5.hTGF-β1 transgenic mice. Am J Pathol. 2011 Feb;178(2):699-708. doi: 10.1016/j.ajpath.2010.10.008. PMID: 21281802; PMCID: PMC3070583. 6: Garcia CC, Russo RC, Guabiraba R, Fagundes CT, Polidoro RB, Tavares LP, Salgado AP, Cassali GD, Sousa LP, Machado AV, Teixeira MM. Platelet-activating factor receptor plays a role in lung injury and death caused by Influenza A in mice. PLoS Pathog. 2010 Nov 4;6(11):e1001171. doi: 10.1371/journal.ppat.1001171. PMID: 21079759; PMCID: PMC2974216. 7: Albuquerque TM, Alencar NM, Figueiredo JG, Figueiredo IS, Teixeira CM, Bitencourt FS, Secco DD, Araújo ES, Ana Maria Leão CA, Ramos MV. Vascular permeability, neutrophil migration and edematogenic effects induced by the latex of Cryptostegia grandiflora. Toxicon. 2009 Jan;53(1):15-23. doi: 10.1016/j.toxicon.2008.10.009. Epub 2008 Oct 17. PMID: 18977378. 8: Oliva J, Bardag-Gorce F, French BA, Li J, McPhaul L, Amidi F, Dedes J, Habibi A, Nguyen S, French SW. Fat10 is an epigenetic marker for liver preneoplasia in a drug-primed mouse model of tumorigenesis. Exp Mol Pathol. 2008 Apr;84(2):102-12. doi: 10.1016/j.yexmp.2007.12.003. Epub 2008 Jan 11. PMID: 18280469; PMCID: PMC2874461. 9: Oliveira SH, Canetti C, Ribeiro RA, Cunha FQ. Neutrophil migration induced by IL-1beta depends upon LTB4 released by macrophages and upon TNF-alpha and IL-1beta released by mast cells. Inflammation. 2008 Feb;31(1):36-46. doi: 10.1007/s10753-007-9047-x. PMID: 17874178. 10: Melnikova V, Bar-Eli M. Inflammation and melanoma growth and metastasis: the role of platelet-activating factor (PAF) and its receptor. Cancer Metastasis Rev. 2007 Dec;26(3-4):359-71. doi: 10.1007/s10555-007-9092-9. PMID: 17721743. 11: Hammamieh R, Sumaida D, Zhang X, Das R, Jett M. Control of the growth of human breast cancer cells in culture by manipulation of arachidonate metabolism. BMC Cancer. 2007 Jul 25;7:138. doi: 10.1186/1471-2407-7-138. PMID: 17651499; PMCID: PMC1940258. 12: Matsumura Y, Byrne SN, Nghiem DX, Miyahara Y, Ullrich SE. A role for inflammatory mediators in the induction of immunoregulatory B cells. J Immunol. 2006 Oct 1;177(7):4810-7. doi: 10.4049/jimmunol.177.7.4810. PMID: 16982922; PMCID: PMC1579249. 13: Coelho MB, Desouza IA, Freire MG, Marangoni S, Antunes E, Macedo ML. Neutrophil migration in mice induced by a mannose-binding lectin isolated from Annona coriacea seeds. Toxicon. 2006 Oct;48(5):529-35. doi: 10.1016/j.toxicon.2006.07.001. Epub 2006 Jul 7. PMID: 16926040. 14: Moreno SE, Alves-Filho JC, Rios-Santos F, Silva JS, Ferreira SH, Cunha FQ, Teixeira MM. Signaling via platelet-activating factor receptors accounts for the impairment of neutrophil migration in polymicrobial sepsis. J Immunol. 2006 Jul 15;177(2):1264-71. doi: 10.4049/jimmunol.177.2.1264. PMID: 16818786. 15: Ranasinghe S, Bolsover S. Microglial calcium responses to platelet- activating factor are inhibited by analogue CAS 99103-16-9 and dihydropyridine PCA 4248 but not by ginkgolide A. Basic Clin Pharmacol Toxicol. 2004 Aug;95(2):87-91. doi: 10.1111/j.1742-7843.2004.950208.x. PMID: 15379786. 16: Beauchamp MH, Marrache AM, Hou X, Gobeil F Jr, Bernier SG, Lachapelle P, Abran D, Quiniou C, Brault S, Peri KG, Roberts J 2nd, Almazan G, Varma DR, Chemtob S. Platelet-activating factor in vasoobliteration of oxygen-induced retinopathy. Invest Ophthalmol Vis Sci. 2002 Oct;43(10):3327-37. PMID: 12356842. 17: Calcerrada MC, Catalan RE, Martinez AM. PAF-stimulated protein tyrosine phosphorylation in hippocampus: involvement of NO synthase. Neurochem Res. 2002 Apr;27(4):313-8. doi: 10.1023/a:1014911329489. PMID: 11958533. 18: Miguel BG, Calcerrada MC, Martín L, Catalán RE, Martínez AM. Increase of phosphoinositide hydrolysis and diacylglycerol production by PAF in isolated rat liver nuclei. Prostaglandins Other Lipid Mediat. 2001 Jul;65(4):159-66. doi: 10.1016/s0090-6980(01)00124-1. PMID: 11444588. 19: Jan CR, Wu SN, Tseng CJ. The ether lipid ET-18-OCH3 increases cytosolic Ca2+ concentrations in Madin Darby canine kidney cells. Br J Pharmacol. 1999 Jul;127(6):1502-10. doi: 10.1038/sj.bjp.0702691. PMID: 10455302; PMCID: PMC1760664. 20: Sharif NA, Wiernas TK, Howe WE, Griffin BW, Offord EA, Pfeifer AM. Human corneal epithelial cell functional responses to inflammatory agents and their antagonists. Invest Ophthalmol Vis Sci. 1998 Dec;39(13):2562-71. PMID: 9856766.

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