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MedKoo Cat#: 414790 | Name: Partricin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Partricin is a polyene antibiotic from Streptomyces aureofaciens; proposed as an antifungal & antiprotozoal agent.

Chemical Structure

Partricin
Partricin
CAS#11096-49-4

Theoretical Analysis

MedKoo Cat#: 414790

Name: Partricin

CAS#: 11096-49-4

Chemical Formula: C58H84N2O19

Exact Mass: 1112.5668

Molecular Weight: 1113.31

Elemental Analysis: C, 62.57; H, 7.61; N, 2.52; O, 27.30

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Partricin; Spa-S132; Spa-S-132; Spa-S 132; Antibiotic spa-8-132
IUPAC/Chemical Name
(19Z,21Z,23Z,25Z,27Z,29Z,31Z)-33-(((2S,3R,4R,5R,6S)-4-amino-3,5-dihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-17-(7-(4-aminophenyl)-5-hydroxy-7-oxoheptan-2-yl)-1,3,5,7,9,13,37-heptahydroxy-18-methyl-11,15-dioxo-16,39-dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxylic acid
InChi Key
NVJUPMZQNWDHTL-GKTUUKTKSA-N
InChi Code
InChI=1S/C58H84N2O19/c1-34-16-14-12-10-8-6-4-5-7-9-11-13-15-17-46(77-57-54(72)52(60)53(71)36(3)76-57)31-49-51(56(73)74)48(69)33-58(75,79-49)32-45(67)28-43(65)26-41(63)24-40(62)25-42(64)27-44(66)30-50(70)78-55(34)35(2)18-23-39(61)29-47(68)37-19-21-38(59)22-20-37/h4-17,19-22,34-36,39-41,43-46,48-49,51-55,57,61-63,65-67,69,71-72,75H,18,23-33,59-60H2,1-3H3,(H,73,74)/b5-4-,8-6-,9-7-,12-10-,13-11-,16-14-,17-15-/t34?,35?,36-,39?,40?,41?,43?,44?,45?,46?,48?,49?,51?,52+,53-,54+,55?,57+,58?/m0/s1
SMILES Code
CC(C1OC(CC(CC(CC(CC(CC(CC(CC2(CC(C(C(O)=O)C(O2)CC(/C=C\C=C/C=C\C=C/C=C\C=C/C=C\C1C)O[C@H]3O[C@H]([C@@H]([C@H]([C@H]3O)N)O)C)O)O)O)O)O)O)=O)O)=O)CCC(CC(c4ccc(N)cc4)=O)O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 1,113.31 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Rimaroli C, Bonabello A, Sala P, Bruzzese T. Pharmacokinetics and tissue distribution of a new partricin A derivative (N-dimethylaminoacetyl-partricin A 2-dimethylaminoethylamide diaspartate) in mice. J Pharm Sci. 2002 May;91(5):1252-8. doi: 10.1002/jps.10134. PMID: 11977101. 2: Clemons KV, Stevens DA. Efficacy of the partricin derivative SPA-S-753 against systemic murine candidosis. J Antimicrob Chemother. 2001 Feb;47(2):183-6. doi: 10.1093/jac/47.2.183. PMID: 11157903. 3: Tweit RC, Pandey RC, Rinehart KL Jr. Characterization of the antifungal and antiprotozoal antibiotic partricin and structural studies on partricins A and B. J Antibiot (Tokyo). 1982 Aug;35(8):997-1012. doi: 10.7164/antibiotics.35.997. PMID: 6897240. 4: Sheehan J, Murphy CD, Caffrey P. New insights into polyene macrolide biosynthesis in Couchioplanes caeruleus. Mol Biosyst. 2017 May 2;13(5):866-873. doi: 10.1039/c7mb00112f. PMID: 28383583. 5: Luna T, Mazzolla R, Romanò G, Blasi E. Potent antifungal effects of a new derivative of partricin A in a murine model of cerebral cryptococcosis. Antimicrob Agents Chemother. 1997 Mar;41(3):706-8. doi: 10.1128/AAC.41.3.706. PMID: 9056019; PMCID: PMC163777. 6: Bruzzese T, Binda I, Ghielmetti G, Notarianni AF. Partricin, an antifungal and antiprotozoal polyene antibiotic. Farmaco Sci. 1974 Apr;29(4):331-4. PMID: 4208028. 7: Bruzzese T, Binda I, Di Nardo A, Ghielmetti G, Riva M. Partricin methyl ester, a semisynthetic polyene antibiotic. Experientia. 1972 Dec 15;28(12):1515-6. doi: 10.1007/BF01957888. PMID: 4631832. 8: Bruzzese T, Galmozzi MR, Buffa G, Sala P, Bonabello A. Pharmacokinetics in rats of n-dimethylaminoacetyl-partricin a 2-dimethylaminoethylamide diascorbate (spk-843). Chemotherapy. 2001 Mar-Apr;47(2):77-85. doi: 10.1159/000048504. PMID: 11173807. 9: Tarnóczi P. Metil-partricina e vaginiti. Ulteriore ricerca clinica controllata [Methyl-partricin and vaginitis. Further controlled clinical research]. Minerva Ginecol. 1976 Jul-Aug;28(7-8):643-8. Italian. PMID: 1037113. 10: Forgács J, Tarnóczy P. La metil-partricina nel trattamento delle flogosi vaginali micotico-protozoarie [Methyl-partricin in the treatment of mycotic and protozoan vaginitis]. Minerva Ginecol. 1973 Apr;25(4):210-7. Italian. PMID: 4575663.