LEI-110 is an inhibitor of adipose phospholipase A2 (AdPLA2; IC50 = 100 nM). It also inhibits HRas-like suppressor 2 (HRASL2), retinoid acid receptor responder protein 3 (RARRES3), and calcium-independent N-acyltransferase (iNAT; IC50s = 158, 158, and 25 nM, respectively). LEI-110 (10 µM) decreases arachidonic acid levels in U2OS cells expressing human AdPLA2 and prevents oleic acid-induced increases in lipid droplet formation in HepG2 cells.
MedKoo Cat#: 112027
Name: LEI-110
CAS#: 2313525-90-3
Chemical Formula: C25H23F3N2O3
Exact Mass: 456.1661
Molecular Weight: 456.47
Elemental Analysis: C, 65.78; H, 5.08; F, 12.49; N, 6.14; O, 10.51
The following data is based on the product molecular weight 456.47 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
