Hydroxyamfetamine | CAS# 103-86-6 | adrenergic property

MedKoo Cat#: 414776 | Name: Hydroxyamfetamine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Hydroxyamfetamine is an indirect-acting sympathomimetic amine with adrenergic property. Hydroxyamphetamine, when applied topically to the eye, stimulates the release of norepinephrine from postganglionic adrenergic nerves resulting in the stimulation of both alpha and beta adrenergic receptors. Local alpha stimulatory effects include dilation of the pupil, increased flow of aqueous humor, and vasoconstriction; whereas beta stimulatory effects include relaxation of the ciliary muscle and a decreased production in aqueous humor.

Chemical Structure

Hydroxyamfetamine

CAS#103-86-6

Theoretical Analysis

MedKoo Cat#: 414776

Name: Hydroxyamfetamine

CAS#: 103-86-6

Chemical Formula: C9H13NO

Exact Mass: 151.0997

Molecular Weight: 151.21

Elemental Analysis: C, 71.49; H, 8.67; N, 9.26; O, 10.58

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

Hydroxyamfetamine; NSC 170995; NSC170995; NSC-170995; BRN2413849; BRN-2413849; BRN 2413849

IUPAC/Chemical Name

4-(2-aminopropyl)phenol

InChi Key

GIKNHHRFLCDOEU-UHFFFAOYSA-N

InChi Code

InChI=1S/C9H13NO/c1-7(10)6-8-2-4-9(11)5-3-8/h2-5,7,11H,6,10H2,1H3

SMILES Code

CC(Cc1ccc(O)cc1)N

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 151.21 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Koka K, Patel BC. Ptosis Correction. 2021 Jul 21. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2021 Jan–. PMID: 30969650. 2: Macri FJ, Cevario SJ. Clonidine. Arch Ophthalmol. 1978 Nov;96(11):2111-3. doi: 10.1001/archopht.1978.03910060491022. PMID: 718505. 3: Walton KA, Buono LM. Horner syndrome. Curr Opin Ophthalmol. 2003 Dec;14(6):357-63. doi: 10.1097/00055735-200312000-00007. PMID: 14615640. 4: Antonio-Santos AA, Santo RN, Eggenberger ER. Pharmacological testing of anisocoria. Expert Opin Pharmacother. 2005 Oct;6(12):2007-13. doi: 10.1517/14656566.6.12.2007. PMID: 16197355. 5: Thevis M, Sigmund G, Thomas A, Vogel M, Walpurgis K, Kwiatkowska D, Geyer H, Schänzer W. Isotope-dilution mass spectrometric quantification of the prodrug lisdexamfetamine in human urine in doping control analysis. Rapid Commun Mass Spectrom. 2014 Apr 15;28(7):781-6. doi: 10.1002/rcm.6844. PMID: 24573809. 6: Mughal M, Longmuir R. Current pharmacologic testing for Horner syndrome. Curr Neurol Neurosci Rep. 2009 Sep;9(5):384-9. doi: 10.1007/s11910-009-0056-z. PMID: 19664368. 7: Lepore FE. Diagnostic pharmacology of the pupil. Clin Neuropharmacol. 1985;8(1):27-37. doi: 10.1097/00002826-198503000-00003. PMID: 3884149. 8: Selhorst JB. The pupil and its disorders. Neurol Clin. 1983 Nov;1(4):859-81. PMID: 6390154. 9: Davagnanam I, Fraser CL, Miszkiel K, Daniel CS, Plant GT. Adult Horner's syndrome: a combined clinical, pharmacological, and imaging algorithm. Eye (Lond). 2013 Mar;27(3):291-8. doi: 10.1038/eye.2012.281. Epub 2013 Feb 1. PMID: 23370415; PMCID: PMC3597883. 10: Burde RM, Thompson HS. Hydroxyamphetamine. A good drug lost? Am J Ophthalmol. 1991 Jan 15;111(1):100-2. doi: 10.1016/s0002-9394(14)76904-1. PMID: 1985468.