ZK53 is a selective activator of mitochondrial caseinolytic protease P ( HsClpP ). Z K53 exhibits therapeutic effects on lung squamous cell carcinoma in vivo. ZK53 treatment causes a decrease of the electron transport chain in a ClpP-dependent manner, which results in declined oxidative phosphorylation and ATP production in lung tumor cells. Mechanistically, ZK53 inhibits the adenoviral early region 2 binding factor targets and activates the ataxia-telangiectasia mutated-mediated DNA damage response, eventually triggering cell cycle arrest. Lastly, ZK53 exhibits therapeutic effects on lung squamous cell carcinoma cells in xenograft and autochthonous mouse models.
MedKoo Cat#: 125579
Name: ZK53
CAS#: 3031789-26-8
Chemical Formula: C19H20BrF2N3O
Exact Mass: 423.0758
Molecular Weight: 424.29
Elemental Analysis: C, 53.79; H, 4.75; Br, 18.83; F, 8.96; N, 9.90; O, 3.77
The following data is based on the product molecular weight 424.29 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
