YHN-86710 is an inhibitor of soluble epoxide hydrolase (sEH; IC50s = 0.155, 0.041, and 0.044 µM for the human, rat, and mouse enzymes, respectively). It is selective for sEH over fatty acid amide hydrolase (FAAH; IC50 = 10.8 µM for the human enzyme). YHN-86710 also inhibits the production of NF-κB (IC50 = 8.80 µM) and activates nuclear factor erythroid 2-related factor 2 (Nrf2; EC50 = 35.24 µM in a transactivation assay) in Neuro2a murine neuroblastoma cells. It increases the paw withdrawal threshold in a mouse model of LPS-induced inflammatory pain when administered at a dose of 100 mg/kg. This product has no formal name. For the convenience of scientific communication, we named it by combining its InChi Key (3 letters from the first letter of each section) with the last 5 digit of its CAS#) according to MedKoo Chemical Nomenclature (https://www.medkoo.com/page/naming).
MedKoo Cat#: 465409
Name: YHN-86710
CAS#: 18286-71-0
Chemical Formula: C25H39NO
Exact Mass: 369.3032
Molecular Weight: 369.59
Elemental Analysis: C, 81.24; H, 10.64; N, 3.79; O, 4.33
| Solvent | mg/mL | mM | |
|---|---|---|---|
| Solubility | |||
| DMF | 30.0 | 81.17 | |
| DMSO | 30.0 | 81.17 | |
| Ethanol | 30.0 | 81.17 |
The following data is based on the product molecular weight 369.59 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
