Teriparatide Free Base | CAS #52232-67-4 (free base) | osteoporosis

MedKoo Cat#: 414768 | Name: Teriparatide Free Base

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WARNING: This product is for research use only, not for human or veterinary use.

Teriparatide Free Base can treat osteoporosis in men and in women who have gone through menopause.

Chemical Structure

Teriparatide Free Base

CAS#52232-67-4 (free base)

Theoretical Analysis

MedKoo Cat#: 414768

Name: Teriparatide Free Base

CAS#: 52232-67-4 (free base)

Chemical Formula: C181H291N55O51S2

Exact Mass: 4115.1309

Molecular Weight: 4117.77

Elemental Analysis: C, 52.80; H, 7.12; N, 18.71; O, 19.82; S, 1.56

Price and Availability

Size	Price	Availability	Quantity
1mg	USD 529.00	2 Weeks

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Related CAS #

99294-94-7 (acetate) 52232-67-4 (free base)

Synonym

Teriparatide Free Base; HSDB7367; HSDB-7367; HSDB 7367; ZT034; ZT-034; ZT 034

IUPAC/Chemical Name

L-Phenylalanine, L-seryl-L-valyl-L-seryl-L-alpha-glutamyl-L-isoleucyl-L-glutaminyl-L-leucyl-L-methionyl-L-histidyl-L-asparaginyl-L-leucylglycyl-L-lysyl-L-histidyl-L-leucyl-L-asparaginyl-L-seryl-L-methionyl-L-alpha-glutamyl-L-arginyl-L-valyl-L-alpha-glutamyl-L-tryptophyl-L-leucyl-L-arginyl-L-lysyl-L-lysyl-L-leucyl-L-glutaminyl-L-alpha-aspartyl-L-valyl-L-histidyl-L-asparaginyl-

InChi Key

OGBMKVWORPGQRR-UMXFMPSGSA-N

InChi Code

InChI=1S/C181H291N55O51S2/c1-21-96(18)146(236-160(267)114(48-53-141(250)251)212-174(281)132(84-239)232-177(284)143(93(12)13)233-147(254)103(185)82-237)178(285)216-111(45-50-134(187)241)155(262)219-119(65-90(6)7)163(270)213-116(55-62-289-20)158(265)224-124(71-100-79-196-86-203-100)167(274)226-126(73-135(188)242)169(276)217-117(63-88(2)3)148(255)201-81-138(245)205-105(39-27-30-56-182)149(256)223-123(70-99-78-195-85-202-99)166(273)221-121(67-92(10)11)164(271)225-128(75-137(190)244)171(278)231-131(83-238)173(280)214-115(54-61-288-19)157(264)210-112(46-51-139(246)247)153(260)208-109(43-34-60-199-181(193)194)159(266)234-144(94(14)15)175(282)215-113(47-52-140(248)249)156(263)222-122(69-98-77-200-104-38-26-25-37-102(98)104)165(272)220-120(66-91(8)9)161(268)209-108(42-33-59-198-180(191)192)151(258)206-106(40-28-31-57-183)150(257)207-107(41-29-32-58-184)152(259)218-118(64-89(4)5)162(269)211-110(44-49-133(186)240)154(261)228-129(76-142(252)253)172(279)235-145(95(16)17)176(283)229-125(72-101-80-197-87-204-101)168(275)227-127(74-136(189)243)170(277)230-130(179(286)287)68-97-35-23-22-24-36-97/h22-26,35-38,77-80,85-96,103,105-132,143-146,200,237-239H,21,27-34,39-76,81-84,182-185H2,1-20H3,(H2,186,240)(H2,187,241)(H2,188,242)(H2,189,243)(H2,190,244)(H,195,202)(H,196,203)(H,197,204)(H,201,255)(H,205,245)(H,206,258)(H,207,257)(H,208,260)(H,209,268)(H,210,264)(H,211,269)(H,212,281)(H,213,270)(H,214,280)(H,215,282)(H,216,285)(H,217,276)(H,218,259)(H,219,262)(H,220,272)(H,221,273)(H,222,263)(H,223,256)(H,224,265)(H,225,271)(H,226,274)(H,227,275)(H,228,261)(H,229,283)(H,230,277)(H,231,278)(H,232,284)(H,233,254)(H,234,266)(H,235,279)(H,236,267)(H,246,247)(H,248,249)(H,250,251)(H,252,253)(H,286,287)(H4,191,192,198)(H4,193,194,199)/t96-,103-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,143-,144-,145-,146-/m0/s1

SMILES Code

CC[C@@H]([C@@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(O)=O)Cc1ccccc1)=O)CC(N)=O)=O)Cc2nc[nH]c2)=O)C(C)C)=O)CC(O)=O)=O)CCC(N)=O)=O)CC(C)C)=O)CCCCN)=O)CCCCN)=O)CCCNC(N)=N)=O)CC(C)C)=O)Cc(c[nH]3)c4c3cccc4)=O)CCC(O)=O)=O)C(C)C)=O)CCCNC(N)=N)=O)CCC(O)=O)=O)CCSC)=O)CO)=O)CC(N)=O)=O)CC(C)C)=O)Cc5nc[nH]c5)=O)CCCCN)=O)=O)CC(C)C)=O)CC(N)=O)=O)Cc6nc[nH]c6)=O)CCSC)=O)CC(C)C)=O)CCC(N)=O)=O)NC([C@@H](NC([C@@H](NC([C@H](C(C)C)NC([C@H](CO)N)=O)=O)CO)=O)CCC(O)=O)=O)C

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 4,117.77 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Lindsay R, Krege JH, Marin F, Jin L, Stepan JJ. Teriparatide for osteoporosis: importance of the full course. Osteoporos Int. 2016 Aug;27(8):2395-410. doi: 10.1007/s00198-016-3534-6. Epub 2016 Feb 22. PMID: 26902094; PMCID: PMC4947115. 2: Shi Z, Zhou H, Pan B, Lu L, Liu J, Kang Y, Yao X, Feng S. Effectiveness of Teriparatide on Fracture Healing: A Systematic Review and Meta-Analysis. PLoS One. 2016 Dec 20;11(12):e0168691. doi: 10.1371/journal.pone.0168691. PMID: 27997614; PMCID: PMC5173248. 3: Leder BZ, Tsai JN, Uihlein AV, Wallace PM, Lee H, Neer RM, Burnett-Bowie SA. Denosumab and teriparatide transitions in postmenopausal osteoporosis (the DATA- Switch study): extension of a randomised controlled trial. Lancet. 2015 Sep 19;386(9999):1147-55. doi: 10.1016/S0140-6736(15)61120-5. Epub 2015 Jul 2. PMID: 26144908; PMCID: PMC4620731. 4: Saag KG, Shane E, Boonen S, Marín F, Donley DW, Taylor KA, Dalsky GP, Marcus R. Teriparatide or alendronate in glucocorticoid-induced osteoporosis. N Engl J Med. 2007 Nov 15;357(20):2028-39. doi: 10.1056/NEJMoa071408. PMID: 18003959. 5: Greenspan SL, Vujevich K, Britton C, Herradura A, Gruen G, Tarkin I, Siska P, Hamlin B, Perera S. Teriparatide for treatment of patients with bisphosphonate- associated atypical fracture of the femur. Osteoporos Int. 2018 Feb;29(2):501-506. doi: 10.1007/s00198-017-4286-7. Epub 2017 Oct 30. PMID: 29085957; PMCID: PMC6468986. 6: Fan G, Zhao Q, Lu P, Chen H, Tan W, Guo W, Liu C, Liu J. Comparison between teriparatide and bisphosphonates for improving bone mineral density in postmenopausal osteoporosis patients: A meta-analysis. Medicine (Baltimore). 2020 Apr;99(15):e18964. doi: 10.1097/MD.0000000000018964. PMID: 32282692; PMCID: PMC7220409. 7: Wang YK, Qin SQ, Ma T, Song W, Jiang RQ, Guo JB, Li K, Zhang YM. Effects of teriparatide versus alendronate for treatment of postmenopausal osteoporosis: A meta-analysis of randomized controlled trials. Medicine (Baltimore). 2017 May;96(21):e6970. doi: 10.1097/MD.0000000000006970. PMID: 28538396; PMCID: PMC5457876. 8: Quattrocchi E, Kourlas H. Teriparatide: a review. Clin Ther. 2004 Jun;26(6):841-54. doi: 10.1016/s0149-2918(04)90128-2. PMID: 15262455. 9: Wanderman N, Alvi M, Yolcu Y, Carlson B, Sebastian A, Bydon M, Freedman B. Is Teriparatide Beneficial to Spinal Fusion Surgery in the Older Patient?: A Narrative Review. Clin Spine Surg. 2019 Jun;32(5):182-190. doi: 10.1097/BSD.0000000000000810. PMID: 30807365. 10: Takada J, Dinavahi R, Miyauchi A, Hamaya E, Hirama T, Libanati C, Nakamura Y, Milmont CE, Grauer A. Relationship between P1NP, a biochemical marker of bone turnover, and bone mineral density in patients transitioned from alendronate to romosozumab or teriparatide: a post hoc analysis of the STRUCTURE trial. J Bone Miner Metab. 2020 May;38(3):310-315. doi: 10.1007/s00774-019-01057-1. Epub 2019 Nov 9. Erratum in: J Bone Miner Metab. 2020 Mar 20;: PMID: 31707465.