Fosgonimeton is a Novel Positive Modulator of the HGF/MET System, Fosgonimeton Promotes Neurotrophic and Procognitive Effects in Models of Dementia. Fosgonimeton attenuates amyloid-beta toxicity in preclinical models of Alzheimer's disease. In vivo, fosgonimeton administration led to functional improvement in an intracerebroventricular Aβ25-35 rat model of AD, as it significantly rescued cognitive function in the passive avoidance test.
MedKoo Cat#: 577283
Name: Fosgonimeton
CAS#: 2093305-05-4 (free base)
Chemical Formula: C27H45N4O8P
Exact Mass: 584.2975
Molecular Weight: 584.65
Elemental Analysis: C, 55.47; H, 7.76; N, 9.58; O, 21.89; P, 5.30
The following data is based on the product molecular weight 584.65 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
