Palonidipine HCl | CAS# 96515-74-1 (HCl) | calcium channel antagonist

MedKoo Cat#: 414743 | Name: Palonidipine HCl

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Palonidipine HCl is a calcium channel antagonist potentially for the treatment of angina pectoris and hypertension.

Chemical Structure

Palonidipine HCl

CAS#96515-74-1 (HCl)

Theoretical Analysis

MedKoo Cat#: 414743

Name: Palonidipine HCl

CAS#: 96515-74-1 (HCl)

Chemical Formula: C29H35ClFN3O6

Exact Mass: 575.2198

Molecular Weight: 576.06

Elemental Analysis: C, 60.47; H, 6.12; Cl, 6.15; F, 3.30; N, 7.29; O, 16.66

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

96515-73-0 (free base) 96515-74-1 (HCl)

Synonym

Palonidipine hydrochloride; Palonidipine HCl; TC-81; TC81; TC 81

IUPAC/Chemical Name

3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(2-fluoro-5-nitrophenyl)-, 2,2-dimethyl-3-(methyl(phenylmethyl)amino)propyl methyl ester, monohydrochloride

InChi Key

OQHXRVQARZHYGQ-UHFFFAOYSA-N

InChi Code

InChI=1S/C29H34FN3O6.ClH/c1-18-24(27(34)38-6)26(22-14-21(33(36)37)12-13-23(22)30)25(19(2)31-18)28(35)39-17-29(3,4)16-32(5)15-20-10-8-7-9-11-20;/h7-14,26,31H,15-17H2,1-6H3;1H

SMILES Code

O=C(C1=C(C)NC(C)=C(C(OC)=O)C1C2=CC([N+]([O-])=O)=CC=C2F)OCC(C)(C)CN(C)CC3=CC=CC=C3.[H]Cl

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 576.06 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Kishimoto T, Okamiya Y, Aoki K, Ota M, Hoshina K, Takeshita T. [Effect of palonidipine hydrochloride (TC-81), a new dihydropyridine derivative, on various myocardial ischemic models]. Nihon Yakurigaku Zasshi. 1993 Aug;102(2):85-100. Japanese. PubMed PMID: 8370558. 2: Okamiya Y, Kishimoto T, Aoki K, Sunakawa K, Hoshina K, Takeshita T. [Effect of palonidipine hydrochloride (TC-81), a novel calcium antagonist, on the canine coronary artery]. Nihon Yakurigaku Zasshi. 1993 Jul;102(1):23-33. Japanese. PubMed PMID: 8335285. 3: Aoki K, Kishimoto T, Sunakawa K, Okamiya Y, Hoshina K, Takeshita T. [Inhibitory effects of palonidipine hydrochloride (TC-81) on contractions induced by various vasoconstrictors in rat aorta]. Nihon Yakurigaku Zasshi. 1993 Apr;101(4):281-8. Japanese. PubMed PMID: 8514210.