Rupatadine Free Base | CAS# 158876-82-5 (free base) | antihistamine

MedKoo Cat#: 414735 | Name: Rupatadine Free Base

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Rupatadine Free Base is a second generation antihistamine and platelet-activating factor antagonist used to treat allergies.

Chemical Structure

Rupatadine Free Base

CAS#158876-82-5 (free base)

Theoretical Analysis

MedKoo Cat#: 414735

Name: Rupatadine Free Base

CAS#: 158876-82-5 (free base)

Chemical Formula: C26H26ClN3

Exact Mass: 415.1815

Molecular Weight: 415.97

Elemental Analysis: C, 75.08; H, 6.30; Cl, 8.52; N, 10.10

Price and Availability

Size	Price	Availability	Quantity
25mg	USD 300.00	2 Weeks

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Related CAS #

158876-82-5 (free base); 182349-12-8 (fumarate)

Synonym

Rupatadine Free Base; Pafinur; Rinialer; Alergoliber; Rupax

IUPAC/Chemical Name

5H-Benzo(5,6)cyclohepta(1,2-b)pyridine, 8-chloro-6,11-dihydro-11-(1-((5-methyl-3-pyridinyl)methyl)-4-piperidinylidene)-

InChi Key

WUZYKBABMWJHDL-UHFFFAOYSA-N

InChi Code

InChI=1S/C26H26ClN3/c1-18-13-19(16-28-15-18)17-30-11-8-20(9-12-30)25-24-7-6-23(27)14-22(24)5-4-21-3-2-10-29-26(21)25/h2-3,6-7,10,13-16H,4-5,8-9,11-12,17H2,1H3

SMILES Code

CC1=CN=CC(CN2CC/C(CC2)=C3C4=CC=C(Cl)C=C4CCC5=CC=CN=C5\3)=C1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 415.97 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

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Rupatadine inhibits colorectal cancer cell proliferation through the PIP5K1A/Akt/CDK2 pathway. Biomed Pharmacother. 2024 Jul;176:116826. doi: 10.1016/j.biopha.2024.116826. Epub 2024 Jun 4. PMID: 38838507. 8: Lin S, Lou Y, Hao R, Shao Y, Yu J, Fang L, Bao M, Yi W, Zhang Y. A single- dose, randomized, open-label, four-period, crossover equivalence trial comparing the clinical similarity of the proposed biosimilar rupatadine fumarate to reference Wystamm® in healthy Chinese subjects. Front Pharmacol. 2024 May 17;15:1328142. doi: 10.3389/fphar.2024.1328142. PMID: 38828454; PMCID: PMC11140027. 9: Ghonim R, Tolba MM, Ibrahim F, El-Awady MI. Environmentally benign liquid chromatographic method for concurrent estimation of four antihistaminic drugs applying factorial design approach. BMC Chem. 2024 Jan 30;18(1):26. doi: 10.1186/s13065-024-01117-2. PMID: 38291482; PMCID: PMC10829218. 10: Zhang J, Su JY, Zheng H, Li H, Deng WP. 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