MedKoo Cat#: 414719 | Name: Selnoflast
Featured New

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Selnoflast, also known as RO-7486967, is an orally active, potent, selective, and reversible small molecule NLRP3 inhibitor with applications in treating patients with moderate to severe active ulcerative colitis.

Chemical Structure

Selnoflast
CAS#2260969-36-4 (free base)

Theoretical Analysis

MedKoo Cat#: 414719

Name: Selnoflast

CAS#: 2260969-36-4 (free base)

Chemical Formula: C20H29N3O3S

Exact Mass: 391.1930

Molecular Weight: 391.53

Elemental Analysis: C, 61.35; H, 7.47; N, 10.73; O, 12.26; S, 8.19

Price and Availability

Size Price Availability Quantity
50mg USD 750.00 2 Weeks
100mg USD 1,350.00 2 Weeks
200mg USD 2,350.00 2 Weeks
500mg USD 3,850.00 2 Weeks
1g USD 5,450.00 2 Weeks
Bulk Inquiry
Buy Now
Add to Cart
Synonym
Selnoflast; RO-7486967; RO7486967; RO 7486967;
IUPAC/Chemical Name
1-ethyl-N-[(1,2,3,5,6,7-hexahydro-s-indacen-4-yl)carbamoyl]piperidine-4-sulfonamide
InChi Key
OHIFQOUPTWBQLE-UHFFFAOYSA-N
InChi Code
InChI=1S/C20H29N3O3S/c1-2-23-11-9-16(10-12-23)27(25,26)22-20(24)21-19-17-7-3-5-14(17)13-15-6-4-8-18(15)19/h13,16H,2-12H2,1H3,(H2,21,22,24)
SMILES Code
O=S(C1CCN(CC)CC1)(NC(NC2=C3CCCC3=CC4=C2CCC4)=O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 391.53 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Klughammer B, Piali L, Nica A, Nagel S, Bailey L, Jochum C, Ignatenko S, Bläuer A, Danilin S, Gulati P, Hayward J, Scepanovic P, Zhang JD, Bhosale S, Chong CF, Christ A. A randomized, double-blind phase 1b study evaluating the safety, tolerability, pharmacokinetics and pharmacodynamics of the NLRP3 inhibitor selnoflast in patients with moderate to severe active ulcerative colitis. Clin Transl Med. 2023 Nov;13(11):e1471. doi: 10.1002/ctm2.1471. PMID: 37962000; PMCID: PMC10644327.