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MedKoo Cat#: 465300 | Name: Podocarpusflavone A
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Podocarpusflavone A is a biflavone that has been found in D. araucarioides and has diverse biological activities. It inhibits dengue virus NS5 RNA-dependent RNA polymerase (DENV-NS5 RdRp; IC50 = 0.75 µM). Podocarpusflavone A also inhibits cathepsin B with an IC50 value of 1.68 µM and inhibits STAT3 in a reporter assay in a concentration-dependent manner. It reduces the production of reactive oxygen species (ROS) and superoxide anions induced by phorbol 12-myristate 13-acetate (PMA) in isolated human neutrophils when used at concentrations of 1 and 10 µM, respectively. Podocarpusflavone A also inhibits aggregation of amyloid-β (1-40) peptide (Aβ40) in a cell-free assay with an IC50 value of 4.9 μM. Podocarpusflavone A (20 µM) decreases viability of A375, MALME-3M, SK-MEL-1, and SK-MEL-5 melanoma cells and reduces tumor growth in an A375 mouse xenograft model when administered at doses of 20 and 40 mg/kg.

Chemical Structure

Podocarpusflavone A
Podocarpusflavone A
CAS#22136-74-9

Theoretical Analysis

MedKoo Cat#: 465300

Name: Podocarpusflavone A

CAS#: 22136-74-9

Chemical Formula: C31H20O10

Exact Mass: 552.1056

Molecular Weight: 552.49

Elemental Analysis: C, 67.39; H, 3.65; O, 28.96

Price and Availability

Size Price Availability Quantity
1mg USD 350.00 2 Weeks
5mg USD 570.00 2 Weeks
10mg USD 850.00 2 Weeks
25mg USD 1,400.00 2 Weeks
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Related CAS #
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Synonym
Podocarpusflavone A; Podocarpusflavone-A;
IUPAC/Chemical Name
8-(5-(5,7-dihydroxy-4-oxo-4H-chromen-2-yl)-2-hydroxyphenyl)-5,7-dihydroxy-2-(4-methoxyphenyl)-4H-chromen-4-one
InChi Key
RBTRUVNXLDXHBJ-UHFFFAOYSA-N
InChi Code
InChI=1S/C31H20O10/c1-39-17-5-2-14(3-6-17)25-13-24(38)30-22(36)11-21(35)28(31(30)41-25)18-8-15(4-7-19(18)33)26-12-23(37)29-20(34)9-16(32)10-27(29)40-26/h2-13,32-36H,1H3
SMILES Code
O=C1C=C(OC2=C1C(O)=CC(O)=C2)C3=CC(C4=C(O)C=C(O)C5=C4OC(C6=CC=C(C=C6)OC)=CC5=O)=C(C=C3)O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 552.49 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: De L, Xing N, Du Q, Guo S, Wang S. Investigating the anti-lung cancer properties of Zhuang medicine Cycas revoluta Thunb. leaves targeting ion channels and transporters through a comprehensive strategy. Comput Biol Chem. 2024 Jul 19;112:108156. doi: 10.1016/j.compbiolchem.2024.108156. Epub ahead of print. PMID: 39067352. 2: Al-Zahrani AA. The Potential Role of Phytochemicals of Juniperus procera in the Treatment of Ovarian Cancer and the Inhibition of Human Topoisomerase II Alpha Activity. Bioinform Biol Insights. 2024 Apr 25;18:11779322241248904. doi: 10.1177/11779322241248904. PMID: 38681095; PMCID: PMC11047251. 3: Mangmool S, Duangrat R, Rujirayunyong T, Anantachoke N. Anti-inflammatory effects of the Thai herbal remedy Yataprasen and biflavonoids isolated from Putranjiva roxburghii in RAW264.7 macrophages. J Ethnopharmacol. 2024 Jun 12;327:117997. doi: 10.1016/j.jep.2024.117997. Epub 2024 Mar 3. PMID: 38442805. 4: Abdul-Rahman AM, Elwekeel A, Alruhaimi RS, Kamel EM, Bin-Ammar A, Mahmoud AM, Moawad AS, Zaki MA. Multi-target action of Garcinia livingstonei extract and secondary metabolites against fatty acid synthase, α-glucosidase, and xanthine oxidase. Saudi Pharm J. 2023 Oct;31(10):101762. doi: 10.1016/j.jsps.2023.101762. Epub 2023 Aug 25. PMID: 37701752; PMCID: PMC10494472. 5: Lim DJ, Song JS, Lee BH, Son YK, Kim Y. Qualitative and Quantitative Analysis of the Major Bioactive Components of Juniperus chinensis L. Using LC- QTOF-MS and LC-MSMS and Investigation of Antibacterial Activity against Pathogenic Bacteria. Molecules. 2023 May 7;28(9):3937. doi: 10.3390/molecules28093937. PMID: 37175347; PMCID: PMC10180426. 6: Zhu B, Han R, Ni Y, Guo H, Liu X, Li J, Wang L. Podocarpusflavone alleviated renal fibrosis in obstructive nephropathy by inhibiting Fyn/Stat3 signaling pathway. J Nat Med. 2023 Jun;77(3):464-475. doi: 10.1007/s11418-023-01685-y. Epub 2023 Mar 8. PMID: 36884159. 7: Sharma M, Mahto JK, Dhaka P, Neetu N, Tomar S, Kumar P. MD simulation and MM/PBSA identifies phytochemicals as bifunctional inhibitors of SARS-CoV-2. J Biomol Struct Dyn. 2022;40(22):12048-12061. doi: 10.1080/07391102.2021.1969285. Epub 2021 Aug 27. PMID: 34448684. 8: Meng H, Pang Y, Liu G, Luo Z, Tan H, Liu X. Podocarpusflavone A inhibits cell growth of skin cutaneous melanoma by suppressing STAT3 signaling. J Dermatol Sci. 2020 Dec;100(3):201-208. doi: 10.1016/j.jdermsci.2020.10.008. Epub 2020 Oct 17. PMID: 33127205. 9: Mercado-Camargo J, Cervantes-Ceballos L, Vivas-Reyes R, Pedretti A, Serrano- García ML, Gómez-Estrada H. Homology Modeling of Leishmanolysin (gp63) from Leishmania panamensis and Molecular Docking of Flavonoids. ACS Omega. 2020 Jun 10;5(24):14741-14749. doi: 10.1021/acsomega.0c01584. PMID: 32596611; PMCID: PMC7315592. 10: Lee S, Park NJ, Bong SK, Jegal J, Park SA, Kim SN, Yang MH. Ameliorative effects of Juniperus rigida fruit on oxazolone- and 2,4-dinitrochlorobenzene- induced atopic dermatitis in mice. J Ethnopharmacol. 2018 Mar 25;214:160-167. doi: 10.1016/j.jep.2017.12.022. Epub 2017 Dec 16. PMID: 29258854. 11: Trang DT, Huyen LT, Nhiem NX, Quang TH, Hang DTT, Yen PH, Tai BH, Anha HLT, Binh NQ, Van Minha C, Van Kiem P. Tirucallane Glycoside from the Leaves of Antidesma bunius and Inhibitory NO Production in BV2 Cells and RAW264.7 Macrophages. Nat Prod Commun. 2016 Jul;11(7):935-937. PMID: 30452166. 12: Wang G, Yao S, Zhang XX, Song H. Rapid Screening and Structural Characterization of Antioxidants from the Extract of Selaginella doederleinii Hieron with DPPH-UPLC-Q-TOF/MS Method. Int J Anal Chem. 2015;2015:849769. doi: 10.1155/2015/849769. Epub 2015 Feb 22. PMID: 25792983; PMCID: PMC4352518. 13: Ito T, Yokota R, Watarai T, Mori K, Oyama M, Nagasawa H, Matsuda H, Iinuma M. Isolation of six isoprenylated biflavonoids from the leaves of Garcinia subelliptica. Chem Pharm Bull (Tokyo). 2013;61(5):551-8. doi: 10.1248/cpb.c12-01057. PMID: 23649198. 14: Coqueiro A, Regasini LO, Skrzek SC, Queiroz MM, Silva DH, da Silva Bolzani V. Free radical scavenging activity of Kielmeyera variabilis (Clusiaceae). Molecules. 2013 Feb 19;18(2):2376-85. doi: 10.3390/molecules18022376. PMID: 23429348; PMCID: PMC6270038. 15: Yeh PH, Shieh YD, Hsu LC, Kuo LM, Lin JH, Liaw CC, Kuo YH. Naturally Occurring Cytotoxic [3'→8″]-Biflavonoids from Podocarpus nakaii. J Tradit Complement Med. 2012 Jul;2(3):220-6. doi: 10.1016/s2225-4110(16)30103-1. PMID: 24716136; PMCID: PMC3942899. 16: Coulerie P, Eydoux C, Hnawia E, Stuhl L, Maciuk A, Lebouvier N, Canard B, Figadère B, Guillemot JC, Nour M. Biflavonoids of Dacrydium balansae with potent inhibitory activity on dengue 2 NS5 polymerase. Planta Med. 2012 May;78(7):672-7. doi: 10.1055/s-0031-1298355. Epub 2012 Mar 12. PMID: 22411725. 17: Chaabi M, Antheaume C, Weniger B, Justiniano H, Lugnier C, Lobstein A. Biflavones of Decussocarpus rospigliosii as phosphodiesterases inhibitors. Planta Med. 2007 Oct;73(12):1284-6. doi: 10.1055/s-2007-990218. Epub 2007 Sep 24. PMID: 17893835. 18: Azebaze AG, Dongmo AB, Meyer M, Ouahouo BM, Valentin A, Laure Nguemfo E, Nkengfack AE, Vierling W. Antimalarial and vasorelaxant constituents of the leaves of Allanblackia monticola (Guttiferae). Ann Trop Med Parasitol. 2007 Jan;101(1):23-30. doi: 10.1179/136485907X157022. PMID: 17244407. 19: Krauze-Baranowska M, Pobłocka L, El-Hela AA. Biflavones from Chamaecyparis obtusa. Z Naturforsch C J Biosci. 2005 Sep-Oct;60(9-10):679-85. doi: 10.1515/znc-2005-9-1004. PMID: 16320608. 20: Abe F, Nagafuji S, Okabe H, Akahane H, Estrada-Muñiz E, Huerta-Reyes M, Reyes-Chilpa R. Trypanocidal constituents in plants 3. Leaves of Garcinia intermedia and heartwood of Calophyllum brasiliense. Biol Pharm Bull. 2004 Jan;27(1):141-3. doi: 10.1248/bpb.27.141. PMID: 14709920.

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